CATH Classification
Domain Context
CATH Clusters
| Superfamily | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal |
| Functional Family |
Enzyme Information
| 1.1.1.299 |
Malate dehydrogenase (NAD(P)(+)).
based on mapping to UniProt Q9YEA1
(S)-malate + NAD(P)(+) = oxaloacetate + NAD(P)H.
-!- This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyzes only the reduction of oxaloacetate, and can use NAD(+) and NADP(+) with similar specific activity. -!- Different from EC 1.1.1.37, EC 1.1.1.82 and EC 1.1.5.4.
|
UniProtKB Entries (1)
| Q9YEA1 |
MDH_AERPE
Aeropyrum pernix K1
Malate dehydrogenase
|
PDB Structure
| PDB | 2D4A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Refolding, characterization and crystal structure of (S)-malate dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.
Biochim.Biophys.Acta
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