CATH Domain 2brfA00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.200	Tumour Suppressor Smad4
	2.60.200.20

Domain Context

CATH Clusters

Superfamily	2.60.200.20
Functional Family	bifunctional polynucleotide phosphatase/kinase

Enzyme Information

3.1.3.32	Polynucleotide 3'-phosphatase. based on mapping to UniProt Q96T60 A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate. -!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.
2.7.1.78	Polynucleotide 5'-hydroxyl-kinase. based on mapping to UniProt Q96T60 ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. -!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.

UniProtKB Entries (1)

PNKP_HUMAN

Homo sapiens

Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB	2BRF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk. Ali, A.A.E., Jukes, R.M., Pearl, L.H., Oliver, A.W. Nucleic Acids Res.