CATH Domain 1zczB01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1380	Methylglyoxal synthase-like domain

Domain Context

CATH Clusters

Superfamily	Methylglyoxal synthase-like domain
Functional Family	Bifunctional purine biosynthesis protein PurH

Enzyme Information

3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt Q9X0X6 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt Q9X0X6 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_THEMA

Thermotoga maritima MSB8

Bifunctional purine biosynthesis protein PurH

PDB Structure

PDB	1ZCZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. Axelrod, H.L., McMullan, D., Krishna, S.S., Miller, M.D., Elsliger, M.A., Abdubek, P., Ambing, E., Astakhova, T., Carlton, D., Chiu, H.J., Clayton, T., Duan, L., Feuerhelm, J., Grzechnik, S.K., Hale, J., Han, G.W., Haugen, J., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Koesema, E., Morse, A.T., Nigoghossian, E., Okach, L., Oommachen, S., Paulsen, J., Quijano, K., Reyes, R., Rife, C.L., van den Bedem, H., Weekes, D., White, A., Wolf, G., Xu, Q., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. Proteins