CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.79 | Nucleoside Triphosphate Pyrophosphohydrolase |
|
3.90.79.10 | Nucleoside Triphosphate Pyrophosphohydrolase |
Domain Context
CATH Clusters
| Superfamily | Nucleoside Triphosphate Pyrophosphohydrolase |
| Functional Family | Nudix hydrolase 2 |
Enzyme Information
| 3.6.1.17 |
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical).
based on mapping to UniProt P50583
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
-!- Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).
|
UniProtKB Entries (1)
| P50583 |
AP4A_HUMAN
Homo sapiens
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
|
PDB Structure
| PDB | 1XSB |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase
J.Biol.Chem.
|
