CATH Domain 1vdlA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.10	DNA helicase RuvA subunit, C-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA helicase RuvA subunit, C-terminal domain
Functional Family	Putative ubiquitin carboxyl-terminal hydrolase 25

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt P57080

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P57080

UBP25_MOUSE

Mus musculus

Ubiquitin carboxyl-terminal hydrolase 25

PDB Structure

PDB	1VDL
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA Doi-Katayama, Y., Hirota, H., Saito, K., Koshiba, S., Kigawa, T., Yokoyama, S. To be Published

Network disruptions