CATH Domain 1tipA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1240	Phosphoglycerate mutase-like

Domain Context

CATH Clusters

Superfamily	Phosphoglycerate mutase-like
Functional Family	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

2.7.1.105	6-phosphofructo-2-kinase. based on mapping to UniProt P07953 ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.
3.1.3.46	Fructose-2,6-bisphosphate 2-phosphatase. based on mapping to UniProt P07953 Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).

UniProtKB Entries (1)

F261_RAT

Rattus norvegicus

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

PDB Structure

PDB	1TIP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of a trapped phosphoenzyme during a catalytic reaction. Lee, Y.H., Olson, T.W., Ogata, C.M., Levitt, D.G., Banaszak, L.J., Lange, A.J. Nat.Struct.Biol.