CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.850 | Fumarylacetoacetate hydrolase; domain 2 |
|
3.90.850.10 | Fumarylacetoacetase-like, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Fumarylacetoacetase-like, C-terminal domain |
| Functional Family | 2-keto-4-pentenoate hydratase |
Enzyme Information
| 4.2.1.80 |
2-oxopent-4-enoate hydratase.
based on mapping to UniProt P77608
(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H(2)O.
-!- The enzyme is involved in the catechol meta-cleavage pathway, a major mechanism for degradation of aromatic compounds. -!- Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the trans-isomer. -!- The enzyme was named when it was thought that the substrate is 2-oxopent-4-enoate. -!- However, it was later found that the actual substrate is its tautomer (2Z)-2-hydroxypenta-2,4-dienoate. -!- In some organisms the enzyme forms a complex with EC 4.1.1.77.
|
UniProtKB Entries (1)
| P77608 |
MHPD_ECOLI
Escherichia coli K-12
2-keto-4-pentenoate hydratase
|
PDB Structure
| PDB | 1SV6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of 2-hydroxypentadienoic acid hydratase from Escherichia Coli
To be Published
|
