CATH Domain 1sj2B04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.420	Peroxidase; domain 2
	1.10.420.10	Peroxidase, domain 2

Domain Context

CATH Clusters

Superfamily	Peroxidase, domain 2
Functional Family	Catalase-peroxidase

Enzyme Information

1.11.1.21

Catalase peroxidase.

based on mapping to UniProt P9WIE5

(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.

-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

P9WIE5

KATG_MYCTU

Mycobacterium tuberculosis H37Rv

Catalase-peroxidase

PDB Structure

PDB	1SJ2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase. Bertrand, T., Eady, N.A.J., Jones, J.N., Jesmin, Nagy, J.M., Jamart-Gregoire, B., Raven, E.L., Brown, K.A. J.Biol.Chem.