CATH Domain 1piiA01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Indole-3-glycerol phosphate synthase

Enzyme Information

4.1.1.48	Indole-3-glycerol-phosphate synthase. based on mapping to UniProt P00909 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C- (3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O. -!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
5.3.1.24	Phosphoribosylanthranilate isomerase. based on mapping to UniProt P00909 N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate. -!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 2.4.2.18, EC 4.1.1.48, EC 4.1.3.27 and EC 4.2.1.20).

UniProtKB Entries (1)

TRPC_ECOLI

Escherichia coli K-12

Tryptophan biosynthesis protein TrpCF

PDB Structure

PDB	1PII
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from Escherichia coli refined at 2.0 A resolution. Wilmanns, M., Priestle, J.P., Niermann, T., Jansonius, J.N. J.Mol.Biol.