CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | 23S rRNA methyltransferase A |
Enzyme Information
| 2.1.1.187 |
23S rRNA (guanine(745)-N(1))-methyltransferase.
based on mapping to UniProt P36999
S-adenosyl-L-methionine + guanine(745) in 23S rRNA = S-adenosyl-L- homocysteine + N(1)-methylguanine(745) in 23S rRNA.
-!- The enzyme specifically methylates guanine(745) at N(1) in 23S rRNA. -!- Formerly EC 2.1.1.51.
|
UniProtKB Entries (1)
| P36999 |
RLMA_ECOLI
Escherichia coli K-12
23S rRNA (guanine(745)-N(1))-methyltransferase
|
PDB Structure
| PDB | 1P91 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.
Proc.Natl.Acad.Sci.Usa
|
