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1 keywords

CATH Domain 1on8B00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.550 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homologous Superfamily 3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Exostosin-like glycosyltransferase 2

Enzyme Information

2.4.1.223
Glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
based on mapping to UniProt Q9ES89
UDP-N-acetyl-alpha-D-glucosamine + [protein]-3-O-(beta-D-GlcA-(1->3)- beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal- (1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
-!- Enzyme involved in the initiation of heparin and heparan sulfate synthesis, transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core. -!- Apparently products of both the human EXTL2 and EXTL3 genes can catalyze this reaction. -!- In Caenorhabditis elegans, the product of the rib-2 gene displays this activity as well as that of EC 2.4.1.224.

UniProtKB Entries (1)

Q9ES89
EXTL2_MOUSE
Mus musculus
Exostosin-like 2

PDB Structure

PDB 1ON8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K., Negishi, M.
J.Biol.Chem.
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