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1 keywords

CATH Domain 1mf4A00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.90 Phospholipase A2
Homologous Superfamily 1.20.90.10 Phospholipase A2 domain

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Acidic phospholipase A2

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P60045
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P60045
PA2A3_NAJSG
Naja sagittifera
Acidic phospholipase A2 3

PDB Structure

PDB 1MF4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features
Singh, R.K., Vikram, P., Makker, J., Jabeen, T., Sharma, S., Dey, S., Kaur, P., Srinivasan, A., Singh, T.P.
Biochemistry
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