CATH Domain 1ht3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.200	Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily	Peptidase S8/S53 domain
Functional Family	Proteinase K

Enzyme Information

3.4.21.64

Peptidase K.

based on mapping to UniProt P06873

Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyzes peptide amides.

-!- From the mold Tritirachium album Limber. -!- Contains two disulfide bridges and one free Cys near the active site His. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16 and EC 3.4.21.14.

UniProtKB Entries (1)

P06873

PRTK_PARAQ

Parengyodontium album

Proteinase K

PDB Structure

PDB	1HT3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mercury induced modifications in the stereochemistry of the active site through Cys-73 in a serine protease--crystal structure of the complex of a partially modified proteinase K with mercury at 1.8 A resolution Gourinath, S., Degenhardt, M., Eschenburg, S., Moore, K., Delucas, L.J., Betzel, C.H., Singh, T.P. Indian J.Biochem.Biophys.