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1 keywords

CATH Domain 1grvB00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.2020  

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Hypoxanthine phosphoribosyltransferase

Enzyme Information

2.4.2.8
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P0A9M2
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.

UniProtKB Entries (1)

P0A9M2
HPRT_ECOLI
Escherichia coli K-12
Hypoxanthine phosphoribosyltransferase

PDB Structure

PDB 1GRV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Free, Imp-, and Gmp- Bound Escherichia Coli Hypoxanthine Phosphoribosyltransferase
Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., De Jersey, J.
Protein Sci.
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