CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Glycerol-3-phosphate dehydrogenase [NAD(P)+] |
Enzyme Information
| 1.1.1.8 |
Glycerol-3-phosphate dehydrogenase (NAD(+)).
based on mapping to UniProt P90551
sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
-!- Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
|
UniProtKB Entries (1)
| P90551 |
GPDA_LEIME
Leishmania mexicana
Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal
|
PDB Structure
| PDB | 1EVY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des.
|
