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1 keywords

CATH Domain 1dgkN02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.367 Hexokinase; domain 1
Homologous Superfamily 3.40.367.20  

Domain Context

CATH Clusters

Superfamily 3.40.367.20
Functional Family Hexokinase 1

Enzyme Information

2.7.1.1
Hexokinase.
based on mapping to UniProt P19367
ATP + D-hexose = ADP + D-hexose 6-phosphate.
-!- D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. -!- ITP and dATP can act as donors.

UniProtKB Entries (1)

P19367
HXK1_HUMAN
Homo sapiens
Hexokinase-1

PDB Structure

PDB 1DGK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
Aleshin, A.E., Kirby, C., Liu, X., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
J.Mol.Biol.
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