CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
| Superfamily | NADP-dependent oxidoreductase domain |
| Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
| 1.1.1.50 |
3-alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
based on mapping to UniProt P23457
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on androsterone and other 3-alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. -!- Si-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.213).
|
UniProtKB Entries (1)
| P23457 |
DIDH_RAT
Rattus norvegicus
3-alpha-hydroxysteroid dehydrogenase
|
PDB Structure
| PDB | 1AFS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure
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