The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: Insulin-like growth factor-binding protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Insulin-like growth factor II binding GO:0031995
Interacting selectively and non-covalently with insulin-like growth factor II.
10 P13384 (/ISS) P13384 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P24853 (/ISS) P24853 (/ISS) P47877 (/ISS) Q29400 (/ISS)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
6 P12843 (/IDA) P18065 (/IDA) P18065 (/IDA) P18065 (/IDA) P18065 (/IDA) Q5KSZ2 (/IDA)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
6 P13384 (/ISS) P13384 (/ISS) P24853 (/ISS) P24853 (/ISS) P47877 (/ISS) Q29400 (/ISS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 P18065 (/TAS) P18065 (/TAS) P18065 (/TAS) P18065 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P18065 (/IPI) P18065 (/IPI) P18065 (/IPI) P18065 (/IPI)
Insulin-like growth factor II binding GO:0031995
Interacting selectively and non-covalently with insulin-like growth factor II.
2 P12843 (/IDA) Q5KSZ2 (/IDA)
Insulin-like growth factor binding GO:0005520
Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
1 P47877 (/IPI)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
1 P12843 (/IMP)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
1 P47877 (/ISO)
Insulin-like growth factor II binding GO:0031995
Interacting selectively and non-covalently with insulin-like growth factor II.
1 P12843 (/IPI)
Insulin-like growth factor II binding GO:0031995
Interacting selectively and non-covalently with insulin-like growth factor II.
1 P47877 (/ISO)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of insulin-like growth factor receptor signaling pathway GO:0043567
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
11 P12843 (/ISS) P13384 (/ISS) P13384 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P24853 (/ISS) P24853 (/ISS) P47877 (/ISS)
(1 more)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
8 E3W6T5 (/ISS) E3W6T5 (/ISS) H9F8W4 (/ISS) I3MGW5 (/ISS) K9MLZ7 (/ISS) P24853 (/ISS) P24853 (/ISS) Q29400 (/ISS)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
7 P12843 (/ISS) P13384 (/ISS) P13384 (/ISS) P24853 (/ISS) P24853 (/ISS) P47877 (/ISS) Q29400 (/ISS)
Regulation of insulin-like growth factor receptor signaling pathway GO:0043567
Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
5 P12843 (/IC) P18065 (/IC) P18065 (/IC) P18065 (/IC) P18065 (/IC)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
4 P18065 (/IDA) P18065 (/IDA) P18065 (/IDA) P18065 (/IDA)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
4 P18065 (/TAS) P18065 (/TAS) P18065 (/TAS) P18065 (/TAS)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
4 P18065 (/TAS) P18065 (/TAS) P18065 (/TAS) P18065 (/TAS)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
3 C9E9W3 (/IDA) P13384 (/IDA) P13384 (/IDA)
Positive regulation of growth GO:0045927
Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
2 P24853 (/IMP) P24853 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q5KSZ2 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P12843 (/IEP)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 P12843 (/IEP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P12843 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P12843 (/IEP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q5KSZ2 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 P12843 (/IEP)
Response to lithium ion GO:0010226
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
1 P12843 (/IEP)
Regeneration GO:0031099
The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
1 Q5KSZ2 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P12843 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 P12843 (/IEP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P12843 (/IEP)
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
1 P47877 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P12843 (/IEP)
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
1 P12843 (/IEP)
Response to steroid hormone GO:0048545
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
1 P12843 (/IEP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P12843 (/IEP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
10 P13384 (/ISS) P13384 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P18065 (/ISS) P24853 (/ISS) P24853 (/ISS) P47877 (/ISS) Q29400 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
10 C9E9W3 (/IDA) P12843 (/IDA) P13384 (/IDA) P13384 (/IDA) P18065 (/IDA) P18065 (/IDA) P18065 (/IDA) P18065 (/IDA) P47877 (/IDA) Q29400 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
10 E3W6T5 (/ISS) E3W6T5 (/ISS) H9F8W4 (/ISS) I3MGW5 (/ISS) K9MLZ7 (/ISS) P13384 (/ISS) P13384 (/ISS) P24853 (/ISS) P24853 (/ISS) Q29400 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P18065 (/TAS) P18065 (/TAS) P18065 (/TAS) P18065 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P18065 (/HDA) P18065 (/HDA) P18065 (/HDA) P18065 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P12843 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P47877 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P47877 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P47877 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q5KSZ2 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P12843 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P47877 (/ISO)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 P12843 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 P47877 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...