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CATH Superfamily 3.90.870.10

DHBP synthase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DHBP synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Bifunctional riboflavin biosynthesis protein RIBA ...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GTP cyclohydrolase II. [EC: 3.5.4.25]
GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D- ribosylamino)pyrimidine + diphosphate.
  • Two C-N bonds are hydrolyzed, releasing formate, with simultaneous removal of the terminal diphosphate.
 8 A0A178UCT4 A0A178UCT4 P47924 P47924 Q0E079 Q6L506 Q6Z234 Q9FN89
3,4-dihydroxy-2-butanone-4-phosphate synthase. [EC: 4.1.99.12]
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
 7 A0A178UCT4 A0A178UCT4 P47924 P47924 Q0E079 Q6NLQ7 Q6Z234