The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Actin; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Actin like 7B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
61 P14883 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS)
(51 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
25 Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS)
(15 more)
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
21 Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS)
(11 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O94630 (/IPI) P38696 (/IPI) P38696 (/IPI) P38696 (/IPI) P38696 (/IPI) P38696 (/IPI) Q641W9 (/IPI) Q8BXF8 (/IPI) Q9Y615 (/IPI) Q9Y615 (/IPI)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
5 P38696 (/IPI) P38696 (/IPI) P38696 (/IPI) P38696 (/IPI) P38696 (/IPI)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
5 Q54HE7 (/ISS) Q54HE9 (/ISS) Q54HF0 (/ISS) Q54L54 (/ISS) Q55CU2 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 Q4R821 (/ISS) Q5XIK1 (/ISS) Q9D9J3 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q8TDG2 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9D9J3 (/ISO)
Endonuclease activity GO:0004519
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
1 Q9U1E8 (/ISO)
Polyphosphate kinase activity GO:0008976
Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).
1 Q54HE7 (/IDA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin polymerization-dependent cell motility involved in migration of symbiont in host GO:0070359
A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell.
43 P14883 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS)
(33 more)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
21 Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS)
(11 more)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
5 P38696 (/IMP) P38696 (/IMP) P38696 (/IMP) P38696 (/IMP) P38696 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
5 Q54HE7 (/ISS) Q54HE9 (/ISS) Q54HF0 (/ISS) Q54L54 (/ISS) Q55CU2 (/ISS)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
5 P38696 (/IMP) P38696 (/IMP) P38696 (/IMP) P38696 (/IMP) P38696 (/IMP)
Mitotic spindle orientation checkpoint GO:0031578
A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
5 P38696 (/IGI) P38696 (/IGI) P38696 (/IGI) P38696 (/IGI) P38696 (/IGI)
Regulation of smoothened signaling pathway GO:0008589
Any process that modulates the frequency, rate or extent of smoothened signaling.
3 Q4R821 (/ISS) Q5XIK1 (/ISS) Q9D9J3 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q4R821 (/ISS) Q5XIK1 (/ISS) Q9D9J3 (/ISS)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9U1E8 (/IDA)
Regulation of smoothened signaling pathway GO:0008589
Any process that modulates the frequency, rate or extent of smoothened signaling.
1 Q8TDG2 (/IDA)
Regulation of smoothened signaling pathway GO:0008589
Any process that modulates the frequency, rate or extent of smoothened signaling.
1 Q9D9J3 (/ISO)
Dynein-driven meiotic oscillatory nuclear movement GO:0030989
Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.
1 O94630 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8TDG2 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9D9J3 (/ISO)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
43 P14883 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS) P86288 (/ISS)
(33 more)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
21 Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS) Q8ILW9 (/TAS)
(11 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 Q32KZ2 (/ISS) Q4R6Q3 (/ISS) Q4R821 (/ISS) Q5XIK1 (/ISS) Q641W9 (/ISS) Q9D9J3 (/ISS) Q9Y615 (/ISS) Q9Y615 (/ISS)
Dynactin complex GO:0005869
A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
6 P38696 (/IDA) P38696 (/IDA) P38696 (/IDA) P38696 (/IDA) P38696 (/IDA) Q9NA98 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P12432 (/IDA) P12433 (/IDA) Q8TDG2 (/IDA) Q9QY83 (/IDA) Q9QY84 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
5 Q54HE7 (/ISS) Q54HE9 (/ISS) Q54HF0 (/ISS) Q54L54 (/ISS) Q55CU2 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q4R821 (/ISS) Q5XIK1 (/ISS) Q9D9J3 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 Q641W9 (/IDA) Q9Y615 (/IDA) Q9Y615 (/IDA)
Male germ cell nucleus GO:0001673
The nucleus of a male germ cell, a reproductive cell in males.
2 Q8BXF8 (/IDA) Q9QY84 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9Y615 (/HDA) Q9Y615 (/HDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 Q9Y615 (/TAS) Q9Y615 (/TAS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
2 Q9Y614 (/TAS) Q9Y614 (/TAS)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
2 P12432 (/IDA) P12433 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8TDG2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9D9J3 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9D9J3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94630 (/HDA)
Dynactin complex GO:0005869
A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
1 O94630 (/IPI)
Kinetoplast GO:0020023
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
1 Q9U1E8 (/ISO)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 Q9QY84 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9QY84 (/ISO)
Cell cortex of cell tip GO:0051285
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
1 O94630 (/IPI)