The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Actin; Chain A, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Heat shock 70 kDa

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 100 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
171 C8Z3H3 (/IPI) G3I8R9 (/IPI) G3I8R9 (/IPI) G3I8R9 (/IPI) O59855 (/IPI) O65719 (/IPI) O65719 (/IPI) P06761 (/IPI) P07823 (/IPI) P07823 (/IPI)
(161 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
94 G3I8R9 (/IDA) G3I8R9 (/IDA) G3I8R9 (/IDA) P07823 (/IDA) P07823 (/IDA) P07823 (/IDA) P09446 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA)
(84 more)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
78 P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV9 (/IDA)
(68 more)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
77 P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV9 (/IPI)
(67 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
70 P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV9 (/IPI)
(60 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
64 B3VHV2 (/IDA) B6EAX2 (/IDA) P08106 (/IDA) P08106 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA)
(54 more)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
63 A0A1D5PFJ6 (/IPI) A0PA16 (/IPI) A0PA16 (/IPI) A0PA16 (/IPI) A0PA16 (/IPI) A0PA16 (/IPI) F1NWP3 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI) P0DMV8 (/IPI)
(53 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
57 P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P11021 (/HDA)
(47 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
52 P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV9 (/HDA)
(42 more)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
52 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV9 (/TAS)
(42 more)
Showing 1 to 10 of 100 entries

There are 365 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
128 A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A061I5U1 (/ISS) A0A087QQM7 (/ISS) A0A087QQM7 (/ISS) A0A087QQM7 (/ISS) A0A087V8L3 (/ISS)
(118 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
127 A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A024R6B5 (/ISS) A0A061I5U1 (/ISS) A0A087QQM7 (/ISS) A0A087QQM7 (/ISS) A0A087QQM7 (/ISS) A0A087V8L3 (/ISS)
(117 more)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
78 A1CEK9 (/ISS) A1DFN8 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS) A2QW80 (/ISS)
(68 more)
Protein refolding GO:0042026
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
64 P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV9 (/IDA)
(54 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
54 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV9 (/TAS)
(44 more)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
54 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV9 (/TAS)
(44 more)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
52 P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA) P0DMV9 (/IDA)
(42 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
50 A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS)
(40 more)
Response to unfolded protein GO:0006986
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
45 P02825 (/NAS) P02825 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS) P11142 (/NAS)
(35 more)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
43 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P11142 (/TAS)
(33 more)
Showing 1 to 10 of 365 entries

There are 219 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
114 B3VHV2 (/IDA) B6EAX2 (/IDA) O65719 (/IDA) O65719 (/IDA) P08106 (/IDA) P08106 (/IDA) P09435 (/IDA) P09435 (/IDA) P09435 (/IDA) P09435 (/IDA)
(104 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
97 B3VHV2 (/IDA) B6EAX2 (/IDA) O59855 (/IDA) P08106 (/IDA) P08106 (/IDA) P08108 (/IDA) P08108 (/IDA) P08108 (/IDA) P09446 (/IDA) P0DMV8 (/IDA)
(87 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
88 O59855 (/IDA) P06761 (/IDA) P08106 (/IDA) P08106 (/IDA) P08108 (/IDA) P08108 (/IDA) P08108 (/IDA) P09446 (/IDA) P0DMV8 (/IDA) P0DMV8 (/IDA)
(78 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
74 P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV9 (/HDA)
(64 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
73 A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS) A2Q0Z1 (/ISS)
(63 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
66 P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV9 (/HDA)
(56 more)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
61 P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV8 (/HDA) P0DMV9 (/HDA)
(51 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
57 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV9 (/TAS)
(47 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
56 P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV8 (/TAS) P0DMV9 (/TAS)
(46 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
55 B9RYP6 (/IDA) P06761 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA) P11021 (/IDA)
(45 more)
Showing 1 to 10 of 219 entries
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