The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SMAD MH1 domain
".
FunFam 5: Mothers against decapentaplegic homolog
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | O96660 (/IPI) O96660 (/IPI) O96660 (/IPI) Q9I9P8 (/IPI) Q9TZQ2 (/IPI) |
Chromatin DNA binding GO:0031490
Interacting selectively and non-covalently with DNA that is assembled into chromatin.
|
4 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) Q9TZQ2 (/IDA) |
Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618
A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.
|
1 | P45896 (/IMP) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q9I9P8 (/IPI) |
There are 41 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
4 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) Q9TZQ2 (/IMP) |
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
4 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) Q9TZQ2 (/IMP) |
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
4 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) Q9TZQ2 (/IMP) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
4 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) Q9TZQ2 (/IMP) |
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
4 | O96660 (/NAS) O96660 (/NAS) O96660 (/NAS) Q9TZQ2 (/NAS) |
Regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis GO:0090256
Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.
|
4 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) Q9TZQ2 (/IMP) |
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) |
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | O96660 (/IGI) O96660 (/IGI) O96660 (/IGI) |
Activin receptor signaling pathway GO:0032924
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Regulation of imaginal disc-derived wing size GO:0044719
Any process that modulates the size of an imaginal disc-derived wing.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
R8 cell fate specification GO:0045464
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Positive regulation of imaginal disc growth GO:0045572
Any process that activates or increases the frequency, rate or extent of imaginal disc growth.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) |
Regulation of synapse structure or activity GO:0050803
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
|
3 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) |
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
3 | O96660 (/IMP) O96660 (/IMP) O96660 (/IMP) |
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
2 | P45896 (/IGI) Q02330 (/IGI) |
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
2 | P45896 (/IMP) Q02330 (/IMP) |
Regulation of mesodermal cell fate specification GO:0042661
Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.
|
2 | P45896 (/IGI) Q02330 (/IGI) |
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
|
2 | P45896 (/IMP) Q02330 (/IMP) |
Pharynx development GO:0060465
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
|
2 | P45896 (/IMP) Q02330 (/IMP) |
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
|
1 | P45896 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q9I9P8 (/IPI) |
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
|
1 | Q9I9P8 (/IGI) |
Post-embryonic development GO:0009791
The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
|
1 | Q02330 (/IGI) |
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q02330 (/IGI) |
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q02330 (/IMP) |
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P45896 (/ISS) |
Positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
|
1 | P45896 (/IGI) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | P45896 (/IMP) |
Positive regulation of cell size GO:0045793
Any process that increases cell size.
|
1 | P45896 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P45896 (/IMP) |
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
|
1 | P45896 (/IMP) |
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
|
1 | P45896 (/IMP) |
Primitive hemopoiesis GO:0060215
A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.
|
1 | Q9I9P8 (/IGI) |
Transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth GO:1901048
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
1 | P45896 (/IGI) |
Transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth GO:1901048
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
1 | P45896 (/IMP) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) P45896 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O96660 (/IDA) O96660 (/IDA) O96660 (/IDA) |
Heteromeric SMAD protein complex GO:0071144
A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
|
3 | O96660 (/IPI) O96660 (/IPI) O96660 (/IPI) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P45896 (/IDA) |