The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Protein tyrosine phosphatase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: receptor-type tyrosine-protein phosphatase gamma i...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
4 B9EKR1 (/ISS) P23471 (/ISS) Q05909 (/ISS) Q62656 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 B9EKR1 (/IPI) P23470 (/IPI) P23471 (/IPI) Q62656 (/IPI)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
3 P23470 (/IDA) P23471 (/IDA) Q62656 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
3 A0A0G2K561 (/NAS) F1LP13 (/NAS) Q8CIN3 (/NAS)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 B9EKR1 (/ISO) Q05909 (/ISO)
Transmembrane receptor protein tyrosine phosphatase activity GO:0005001
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
2 P23470 (/TAS) P23471 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 B9EKR1 (/ISS) Q62656 (/ISS)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 B9EKR1 (/IMP)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P23471 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 B9EKR1 (/ISO)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q62656 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q62656 (/IMP)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 B9EKR1 (/ISO)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 B9EKR1 (/ISS)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 Q62656 (/IPI)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 B9EKR1 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P23470 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q05909 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q05909 (/ISS)

There are 61 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
4 A0A0G2K561 (/IEP) F1LP13 (/IEP) Q62656 (/IEP) Q8CIN3 (/IEP)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 A0A0G2K561 (/IDA) F1LP13 (/IDA) Q8CIN3 (/IDA)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
3 B9EKR1 (/ISS) P23471 (/ISS) Q62656 (/ISS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
2 P23471 (/ISS) Q62656 (/ISS)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
2 P23471 (/ISS) Q62656 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 P23471 (/ISS) Q62656 (/ISS)
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
2 P23471 (/ISS) Q62656 (/ISS)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
2 B9EKR1 (/ISS) P23471 (/ISS)
Regulation of oligodendrocyte progenitor proliferation GO:0070445
Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.
2 P23471 (/ISS) Q62656 (/ISS)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 B9EKR1 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 Q62656 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 B9EKR1 (/ISO)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P23471 (/TAS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23470 (/TAS)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
1 B9EKR1 (/IDA)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
1 Q62656 (/IDA)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
1 B9EKR1 (/ISO)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 P23471 (/TAS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 B9EKR1 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q62656 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 B9EKR1 (/ISO)
Visual learning GO:0008542
Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.
1 Q62656 (/IEP)
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
1 P23470 (/IMP)
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
1 Q05909 (/ISO)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 Q62656 (/IDA)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 B9EKR1 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q62656 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 B9EKR1 (/ISO)
Negative regulation of neuron projection development GO:0010977
Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q05909 (/ISO)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23471 (/TAS)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q62656 (/IEP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q62656 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 B9EKR1 (/ISO)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 B9EKR1 (/IMP)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 Q62656 (/IDA)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 B9EKR1 (/IMP)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 B9EKR1 (/ISO)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 B9EKR1 (/IDA)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 Q62656 (/IDA)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 B9EKR1 (/ISO)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q62656 (/IEP)
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
1 Q62656 (/IEP)
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
1 B9EKR1 (/IMP)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
1 Q62656 (/IMP)
Positive regulation of oligodendrocyte differentiation GO:0048714
Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
1 B9EKR1 (/ISO)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
1 Q62656 (/IMP)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
1 B9EKR1 (/ISO)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 Q62656 (/IDA)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 B9EKR1 (/ISO)
Regulation of oligodendrocyte progenitor proliferation GO:0070445
Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.
1 B9EKR1 (/IMP)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
1 Q62656 (/IDA)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
1 B9EKR1 (/ISO)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
1 Q62656 (/IMP)
Positive regulation of Schwann cell migration GO:1900149
Any process that activates or increases the frequency, rate or extent of Schwann cell migration.
1 B9EKR1 (/ISO)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 Q62656 (/IDA)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
1 B9EKR1 (/ISO)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q05909 (/IMP)
Negative regulation of dendrite development GO:2000171
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.
1 Q62656 (/IDA)
Negative regulation of dendrite development GO:2000171
Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.
1 B9EKR1 (/ISO)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
1 Q62656 (/IMP)
Positive regulation of neuron migration GO:2001224
Any process that activates or increases the frequency, rate or extent of neuron migration.
1 B9EKR1 (/ISO)

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 A0A0G2K561 (/IDA) F1LP13 (/IDA) Q62656 (/IDA) Q8CIN3 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 B9EKR1 (/ISO) Q05909 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 B9EKR1 (/IDA) P23471 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P23470 (/TAS) P23471 (/TAS)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 B9EKR1 (/ISS) P23471 (/ISS)
Perineuronal net GO:0072534
A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
2 B9EKR1 (/IDA) Q62656 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q62656 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 B9EKR1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 B9EKR1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P23471 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q62656 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 B9EKR1 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q62656 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 B9EKR1 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q62656 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 B9EKR1 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q62656 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 B9EKR1 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q62656 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 B9EKR1 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q62656 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 B9EKR1 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 B9EKR1 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q62656 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 B9EKR1 (/ISO)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q62656 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 B9EKR1 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q62656 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 B9EKR1 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q62656 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 B9EKR1 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 A0A1D5PMB2 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 B9EKR1 (/EXP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 B9EKR1 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 Q62656 (/IDA)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 B9EKR1 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P23470 (/HDA)
Perineuronal net GO:0072534
A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain.
1 B9EKR1 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q62656 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 B9EKR1 (/ISO)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q62656 (/IDA)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 B9EKR1 (/ISO)
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