The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Medium-chain alcohol dehydrogenases, catalytic domain
".
FunFam 8: Sorbitol dehydrogenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
L-iditol 2-dehydrogenase activity GO:0003939
Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
|
10 | P07846 (/IDA) P0DMQ6 (/IDA) P35497 (/IDA) P35497 (/IDA) P35497 (/IDA) P35497 (/IDA) Q00796 (/IDA) Q64442 (/IDA) Q9FJ95 (/IDA) Q9FJ95 (/IDA) |
L-iditol 2-dehydrogenase activity GO:0003939
Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
|
9 | A2QM95 (/IMP) A2QM95 (/IMP) A2QM95 (/IMP) P35497 (/IMP) P35497 (/IMP) P35497 (/IMP) P35497 (/IMP) Q07786 (/IMP) Q07786 (/IMP) |
L-iditol 2-dehydrogenase activity GO:0003939
Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
|
9 | O96299 (/ISS) O97479 (/ISS) P35497 (/ISS) P35497 (/ISS) P35497 (/ISS) P35497 (/ISS) Q00796 (/ISS) Q07786 (/ISS) Q07786 (/ISS) |
D-xylulose reductase activity GO:0046526
Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH.
|
8 | Q07993 (/IDA) Q86ZV0 (/IDA) Q86ZV0 (/IDA) Q86ZV0 (/IDA) Q86ZV0 (/IDA) Q876R2 (/IDA) Q876R2 (/IDA) Q876R2 (/IDA) |
L-iditol 2-dehydrogenase activity GO:0003939
Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
|
4 | F7A1C3 (/TAS) P07846 (/TAS) Q58D31 (/TAS) W5QIT0 (/TAS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
3 | P07846 (/IDA) P27867 (/IDA) Q00796 (/IDA) |
L-iditol 2-dehydrogenase activity GO:0003939
Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.
|
2 | P36624 (/ISO) Q64442 (/ISO) |
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
2 | P0DMQ6 (/IDA) Q00796 (/IDA) |
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
2 | P07846 (/TAS) W5QIT0 (/TAS) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q64442 (/ISO) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q00796 (/ISS) |
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
1 | Q00796 (/NAS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P27867 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q00796 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q64442 (/ISO) |
D-xylulose reductase activity GO:0046526
Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH.
|
1 | P36624 (/ISO) |
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
1 | Q64442 (/ISO) |
There are 37 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
8 | P07846 (/ISS) P27867 (/ISS) Q00796 (/ISS) Q4R639 (/ISS) Q4R639 (/ISS) Q4R639 (/ISS) Q58D31 (/ISS) Q5R5F3 (/ISS) |
Hexose metabolic process GO:0019318
The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
|
4 | P35497 (/IEP) P35497 (/IEP) P35497 (/IEP) P35497 (/IEP) |
L-xylitol catabolic process to xylulose 5-phosphate GO:0019697
The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate.
|
4 | Q86ZV0 (/IMP) Q86ZV0 (/IMP) Q86ZV0 (/IMP) Q86ZV0 (/IMP) |
D-xylose catabolic process GO:0042843
The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.
|
4 | Q86ZV0 (/IC) Q86ZV0 (/IC) Q86ZV0 (/IC) Q86ZV0 (/IC) |
Sorbitol catabolic process GO:0006062
The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
3 | A2QM95 (/IMP) A2QM95 (/IMP) A2QM95 (/IMP) |
Fructose biosynthetic process GO:0046370
The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.
|
3 | P07846 (/TAS) Q00796 (/TAS) W5QIT0 (/TAS) |
Sorbitol catabolic process GO:0006062
The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
2 | P0DMQ6 (/IDA) Q00796 (/IDA) |
Sorbitol catabolic process GO:0006062
The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
2 | P07846 (/TAS) W5QIT0 (/TAS) |
Hexose metabolic process GO:0019318
The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
|
2 | Q07786 (/ISS) Q07786 (/ISS) |
Xylulose biosynthetic process GO:0005999
The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose.
|
1 | Q07993 (/IDA) |
Fructose metabolic process GO:0006000
The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
|
1 | P0DMQ6 (/IDA) |
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
1 | Q00796 (/TAS) |
Sorbitol metabolic process GO:0006060
The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
1 | Q64442 (/IDA) |
Sorbitol biosynthetic process GO:0006061
The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
1 | P0DMQ6 (/NAS) |
Sorbitol catabolic process GO:0006062
The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group.
|
1 | Q64442 (/ISO) |
NADH oxidation GO:0006116
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD.
|
1 | P0DMQ6 (/IDA) |
NADH regeneration GO:0006735
A metabolic process that generates a pool of NADH by the reduction of NAD+.
|
1 | P0DMQ6 (/IDA) |
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
1 | P27867 (/IEP) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P27867 (/IDA) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | Q64442 (/ISO) |
Hexitol catabolic process GO:0019407
The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule.
|
1 | P36624 (/IC) |
Glucuronate catabolic process to xylulose 5-phosphate GO:0019640
The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.
|
1 | Q00796 (/TAS) |
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
1 | Q64442 (/IDA) |
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
|
1 | Q00796 (/NAS) |
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | P27867 (/IEP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P27867 (/IEP) |
Fructose biosynthetic process GO:0046370
The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.
|
1 | Q00796 (/IDA) |
Fructose biosynthetic process GO:0046370
The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.
|
1 | Q64442 (/ISO) |
Fructose biosynthetic process GO:0046370
The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose.
|
1 | P0DMQ6 (/NAS) |
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | P27867 (/IDA) |
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | Q64442 (/ISO) |
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | P27867 (/IDA) |
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | Q64442 (/ISO) |
L-xylitol catabolic process GO:0051160
The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group.
|
1 | Q00796 (/IDA) |
L-xylitol catabolic process GO:0051160
The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group.
|
1 | Q64442 (/ISO) |
L-xylitol metabolic process GO:0051164
The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets.
|
1 | Q00796 (/IDA) |
L-xylitol metabolic process GO:0051164
The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets.
|
1 | Q64442 (/ISO) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
|
8 | P07846 (/ISS) P27867 (/ISS) Q00796 (/ISS) Q4R639 (/ISS) Q4R639 (/ISS) Q4R639 (/ISS) Q58D31 (/ISS) Q5R5F3 (/ISS) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | P07846 (/TAS) P0DMQ6 (/TAS) W5QIT0 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q9FJ95 (/IDA) Q9FJ95 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9FJ95 (/IDA) Q9FJ95 (/IDA) |
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
|
2 | Q9FJ95 (/IDA) Q9FJ95 (/IDA) |
Hyphal cell wall GO:0030446
The cell wall surrounding a fungal hypha.
|
2 | A0A1D8PUB4 (/IDA) A0A1D8PUB4 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q00796 (/TAS) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q64442 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P36624 (/HDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q00796 (/TAS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q00796 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q64442 (/ISO) |
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
|
1 | Q64442 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q00796 (/HDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q00796 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q64442 (/ISO) |