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CATH Superfamily 3.90.1480.20

Glycosyl transferase family 29

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycosyl transferase family 29
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: ST3 beta-galactoside alpha-2,3-sialyltransferase 4

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase. [EC: 2.4.99.2]
CMP-N-acetyl-beta-neuraminate + a beta-D-galactosyl-(1->3)-N-acetyl-beta- D-galactosaminyl-R = CMP + an N-acetyl-alpha-neuraminyl-(2->3)-beta-D- galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-R.
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl- D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • When acting on gangloside GM1a, it forms gangloside GD1a.
 4 P61130 P61131 Q11206 Q91Y74
Beta-galactoside alpha-2,3-sialyltransferase. [EC: 2.4.99.4]
CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R.
  • The acceptor is Gal-beta-1,3-GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid.
  • Lactose can also act as acceptor.
  • May be identical with EC 2.4.99.2.
 3 P61130 P61131 Q11206
N-acetyllactosaminide alpha-2,3-sialyltransferase. [EC: 2.4.99.6]
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D- galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
  • Formerly EC 2.4.99.10.
 1 Q91Y74