The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycosyl transferase family 29
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltra...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828
Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
17 O35696 (/IDA) O43173 (/IDA) Q64689 (/IDA) Q64692 (/IDA) Q64692 (/IDA) Q92186 (/IDA) Q92186 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA)
(7 more)
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
13 O43173 (/IC) Q92186 (/IC) Q92186 (/IC) Q92187 (/IC) Q92187 (/IC) Q92187 (/IC) Q92187 (/IC) Q92187 (/IC) Q92187 (/IC) Q92187 (/IC)
(3 more)
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828
Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
11 A7MCS5 (/ISS) B0CN48 (/ISS) F1R0F8 (/ISS) Q4KMD8 (/ISS) Q50J33 (/ISS) Q50J35 (/ISS) Q6KBZ7 (/ISS) Q6KC03 (/ISS) Q6KC05 (/ISS) Q6ZXC9 (/ISS)
(1 more)
Sialyltransferase activity GO:0008373
Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
10 O43173 (/IDA) Q1LVN2 (/IDA) Q4KMD8 (/IDA) Q50J31 (/IDA) Q50J33 (/IDA) Q6KC03 (/IDA) Q7ZU51 (/IDA) Q8K4T1 (/IDA) Q8K4T1 (/IDA) Q8QH83 (/IDA)
Sialyltransferase activity GO:0008373
Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
6 P61644 (/ISS) P61647 (/ISS) Q1LVN2 (/ISS) Q50J31 (/ISS) Q7ZU51 (/ISS) Q8QH83 (/ISS)
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity GO:0003828
Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.
4 O35696 (/ISO) Q64689 (/ISO) Q64692 (/ISO) Q64692 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O35696 (/IPI) Q64690 (/IPI)
Sialyltransferase activity GO:0008373
Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
2 A1KQY6 (/TAS) Q07977 (/TAS)
Sialyltransferase activity GO:0008373
Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.
1 Q64689 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O43173 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q64689 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ganglioside biosynthetic process GO:0001574
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
15 O43173 (/IDA) Q8K4T1 (/IDA) Q8K4T1 (/IDA) Q92186 (/IDA) Q92186 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA)
(5 more)
Oligosaccharide metabolic process GO:0009311
The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
15 O43173 (/IDA) Q8K4T1 (/IDA) Q8K4T1 (/IDA) Q92186 (/IDA) Q92186 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA)
(5 more)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
13 O43173 (/IDA) Q92186 (/IDA) Q92186 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA)
(3 more)
N-glycan processing GO:0006491
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.
13 O43173 (/IDA) Q92186 (/IDA) Q92186 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA) Q92187 (/IDA)
(3 more)
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
12 Q92186 (/TAS) Q92186 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS)
(2 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
12 Q92186 (/TAS) Q92186 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS)
(2 more)
Ganglioside biosynthetic process GO:0001574
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
4 O35696 (/ISO) Q64689 (/ISO) Q64692 (/ISO) Q64692 (/ISO)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
4 O35696 (/ISO) Q64689 (/ISO) Q64692 (/ISO) Q64692 (/ISO)
N-glycan processing GO:0006491
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.
4 O35696 (/ISO) Q64689 (/ISO) Q64692 (/ISO) Q64692 (/ISO)
Oligosaccharide metabolic process GO:0009311
The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
4 O35696 (/ISO) Q64689 (/ISO) Q64692 (/ISO) Q64692 (/ISO)
Olfactory nerve formation GO:0021628
The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.
4 A7MCS5 (/IMP) F1R0F8 (/IMP) Q50J35 (/IMP) Q6KBZ7 (/IMP)
Olfactory placode morphogenesis GO:0071699
The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
4 A7MCS5 (/IMP) F1R0F8 (/IMP) Q50J35 (/IMP) Q6KBZ7 (/IMP)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
3 O43173 (/IDA) Q8K4T1 (/IDA) Q8K4T1 (/IDA)
Blastocyst hatching GO:0001835
The hatching of the cellular blastocyst from the zona pellucida.
2 Q8K4T1 (/IMP) Q8K4T1 (/IMP)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
2 Q92186 (/TAS) Q92186 (/TAS)
N-glycan processing GO:0006491
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.
2 P61644 (/ISS) Q64689 (/ISS)
Protein O-linked glycosylation GO:0006493
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
2 Q8K4T1 (/IDA) Q8K4T1 (/IDA)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
2 B0CN48 (/IMP) Q6KC05 (/IMP)
Glycolipid biosynthetic process GO:0009247
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
2 Q8K4T1 (/IDA) Q8K4T1 (/IDA)
Carbohydrate biosynthetic process GO:0016051
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
2 Q8K4T1 (/IDA) Q8K4T1 (/IDA)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
2 B0CN48 (/IMP) Q6KC05 (/IMP)
Protein sialylation GO:1990743
A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
2 P61644 (/ISS) Q64689 (/ISS)
Ganglioside biosynthetic process GO:0001574
The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
1 P61647 (/ISS)
Protein O-linked glycosylation GO:0006493
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
1 P61647 (/ISS)
Glycosphingolipid biosynthetic process GO:0006688
The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
1 O43173 (/TAS)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 A1KQY6 (/TAS)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
1 Q64689 (/ISO)
Glycoprotein metabolic process GO:0009100
The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
1 P61647 (/ISS)
Glycolipid biosynthetic process GO:0009247
The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
1 P61647 (/ISS)
Oligosaccharide metabolic process GO:0009311
The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
1 P61647 (/ISS)
Carbohydrate biosynthetic process GO:0016051
The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
1 P61647 (/ISS)
Protein sialylation GO:1990743
A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
1 O43173 (/IDA)
Protein sialylation GO:1990743
A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
1 Q64689 (/ISO)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
14 O43173 (/TAS) P61647 (/TAS) Q92186 (/TAS) Q92186 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS) Q92187 (/TAS)
(4 more)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 O35696 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
1 O35696 (/IDA)
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