The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 176: Thyrotropin receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Thyroid-stimulating hormone receptor activity GO:0004996
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
6 P14763 (/ISS) P21463 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
6 P14763 (/ISS) P21463 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Thyroid-stimulating hormone receptor activity GO:0004996
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
2 P16473 (/IMP) P21463 (/IMP)
Thyroid-stimulating hormone receptor activity GO:0004996
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
1 P47750 (/IDA)
Thyroid-stimulating hormone receptor activity GO:0004996
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
1 P47750 (/ISO)
Thyroid-stimulating hormone receptor activity GO:0004996
Combining with thyroid-stimulating hormone to initiate a change in cell activity.
1 P16473 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P16473 (/IPI)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 P16473 (/IMP)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 P47750 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P16473 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P47750 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Cellular response to glycoprotein GO:1904588
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Cellular response to thyrotropin-releasing hormone GO:1905229
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Thyroid-stimulating hormone signaling pathway GO:0038194
The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription.
6 P14763 (/ISS) P21463 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
3 G3V6J1 (/ISS) P16473 (/ISS) P21463 (/ISS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P16473 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P47750 (/ISO)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P16473 (/TAS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
1 P16473 (/TAS)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P47750 (/IDA)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P16473 (/IMP)
Adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).
1 P47750 (/ISO)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 P16473 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P21463 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P47750 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P16473 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P47750 (/IMP)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
1 P47750 (/IMP)
Thyroid-stimulating hormone signaling pathway GO:0038194
The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription.
1 P16473 (/IMP)
Thyroid-stimulating hormone signaling pathway GO:0038194
The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription.
1 P47750 (/ISO)
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
1 P47750 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 P47750 (/IMP)
Inner ear receptor cell development GO:0060119
The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P47750 (/IMP)
Inner ear receptor cell stereocilium organization GO:0060122
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells.
1 P47750 (/IMP)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
1 P47750 (/IMP)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
1 P47750 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 P47750 (/IMP)
Cellular response to glycoprotein GO:1904588
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.
1 P16473 (/IMP)
Cellular response to glycoprotein GO:1904588
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.
1 P47750 (/ISO)
Cellular response to thyrotropin-releasing hormone GO:1905229
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
1 P16473 (/IMP)
Cellular response to thyrotropin-releasing hormone GO:1905229
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.
1 P47750 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
7 P14763 (/ISS) P21463 (/ISS) P47750 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P14763 (/ISS) P21463 (/ISS) P56495 (/ISS) Q27987 (/ISS) Q8SPP9 (/ISS) Q9BGN4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P16473 (/IDA) P47750 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P47750 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P16473 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P16473 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P16473 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P16473 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P47750 (/ISO)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P16473 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P47750 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P21463 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P47750 (/ISO)