The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: N-acyl-phosphatidylethanolamine-hydrolyzing phosph...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
3 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q769K2 (/ISS)
N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
2 Q6IQ20 (/IDA) Q8BH82 (/IDA)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
1 Q769K2 (/IDA)
Phospholipase activity GO:0004620
Catalysis of the hydrolysis of a glycerophospholipid.
1 Q8BH82 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q6IQ20 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q8BH82 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q6IQ20 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8BH82 (/ISO)
N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
1 Q8BH82 (/IMP)
N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
1 Q8BH82 (/ISO)
N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).
1 Q6IQ20 (/TAS)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS)
Host-mediated regulation of intestinal microbiota composition GO:0048874
The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 Q6IQ20 (/TAS)
Temperature homeostasis GO:0001659
A homeostatic process in which an organism modulates its internal body temperature.
1 Q8BH82 (/IMP)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q769K2 (/IDA)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q8BH82 (/ISO)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q769K2 (/IEP)
Response to isolation stress GO:0035900
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.
1 Q769K2 (/IEP)
Host-mediated regulation of intestinal microbiota composition GO:0048874
The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut.
1 Q8BH82 (/IMP)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 Q8BH82 (/IMP)
N-acylethanolamine metabolic process GO:0070291
The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.
1 Q8BH82 (/IDA)
N-acylethanolamine metabolic process GO:0070291
The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.
1 Q8BH82 (/IMP)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
1 Q6IQ20 (/IDA)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
1 Q8BH82 (/IMP)
N-acylphosphatidylethanolamine metabolic process GO:0070292
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.
1 Q8BH82 (/ISO)
Positive regulation of brown fat cell differentiation GO:0090336
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
1 Q8BH82 (/IMP)
Negative regulation of eating behavior GO:1903999
Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior.
1 Q769K2 (/IMP)
Negative regulation of eating behavior GO:1903999
Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior.
1 Q8BH82 (/ISO)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4 Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 Q5RCU3 (/ISS) Q6IQ20 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 Q58CN9 (/ISS) Q5RCU3 (/ISS) Q769K2 (/ISS) Q8BH82 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q58CN9 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q58CN9 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q58CN9 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q6IQ20 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q8BH82 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6IQ20 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8BH82 (/ISO)
Photoreceptor outer segment membrane GO:0042622
The membrane surrounding the outer segment of a vertebrate photoreceptor.
1 Q6IQ20 (/TAS)
Membrane-bounded organelle GO:0043227
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q769K2 (/IDA)
Membrane-bounded organelle GO:0043227
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8BH82 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q6IQ20 (/HDA)
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