The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Mannitol-specific EII; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Anion exchange protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O88343 (/IPI) Q9GL77 (/IPI) Q9Y6R1 (/IPI) Q9Y6R1 (/IPI) Q9Y6R1 (/IPI)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
5 A0A2R8PYB9 (/IDA) A0A2R8QD45 (/IDA) B3DGX8 (/IDA) F1QHT2 (/IDA) Q3ZMH2 (/IDA)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
5 O88343 (/ISS) Q4U116 (/ISS) Q9GL77 (/ISS) Q9JI66 (/ISS) Q9XSZ4 (/ISS)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
4 Q9JI66 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
3 Q9Y6R1 (/IMP) Q9Y6R1 (/IMP) Q9Y6R1 (/IMP)
Inorganic anion exchanger activity GO:0005452
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out).
1 Q6RI88 (/TAS)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
1 O88343 (/ISO)
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
1 Q9BY07 (/NAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O88343 (/ISO)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 O88343 (/IDA) Q9Y6R1 (/IDA) Q9Y6R1 (/IDA) Q9Y6R1 (/IDA)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 Q4U116 (/ISS) Q9GL77 (/ISS) Q9JI66 (/ISS) Q9XSZ4 (/ISS)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 Q9BY07 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS)
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Renal system process GO:0003014
A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Regulation of systemic arterial blood pressure GO:0003073
The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Regulation of pH GO:0006885
Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
3 O88343 (/TAS) Q6RI88 (/TAS) Q9JI66 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Cerebrospinal fluid secretion GO:0033326
The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Mitochondrion distribution GO:0048311
Any process that establishes the spatial arrangement of mitochondria between and within cells.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
3 D3YVG0 (/IMP) D3YX36 (/IMP) E9Q3M5 (/IMP)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O88343 (/ISO)
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6RI88 (/TAS)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O88343 (/IGI)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O88343 (/ISS)
Bicarbonate transport GO:0015701
The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9BY07 (/NAS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 O88343 (/TAS) Q9JI66 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
5 O88343 (/ISS) Q4U116 (/ISS) Q9GL77 (/ISS) Q9JI66 (/ISS) Q9XSZ4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q9BY07 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS) Q9Y6R1 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
3 Q9Y6R1 (/IDA) Q9Y6R1 (/IDA) Q9Y6R1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q9Y6R1 (/HDA) Q9Y6R1 (/HDA) Q9Y6R1 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9BY07 (/NAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6RI88 (/TAS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 O88343 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...