The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Histone deacetylase domain
".
FunFam 1: Histone deacetylase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
16 |
G5EB64 (/IMP)
G5EB64 (/IMP)
G5EB64 (/IMP)
O22446 (/IMP)
O22446 (/IMP)
O59702 (/IMP)
P32561 (/IMP)
P32561 (/IMP)
P32561 (/IMP)
P32561 (/IMP)
(6 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
O17695 (/IPI)
O22446 (/IPI)
O22446 (/IPI)
O59702 (/IPI)
P32561 (/IPI)
P32561 (/IPI)
P32561 (/IPI)
P32561 (/IPI)
P32561 (/IPI)
P32561 (/IPI)
(5 more) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
13 |
G5EB64 (/IDA)
G5EB64 (/IDA)
G5EB64 (/IDA)
O17695 (/IDA)
O22446 (/IDA)
O22446 (/IDA)
P32561 (/IDA)
P32561 (/IDA)
P32561 (/IDA)
P32561 (/IDA)
(3 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
7 | P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
7 | P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
6 | G5ECH0 (/ISS) O22446 (/ISS) O22446 (/ISS) Q9FML2 (/ISS) Q9FML2 (/ISS) Q9FML2 (/ISS) |
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
3 | G5EB64 (/ISA) G5EB64 (/ISA) G5EB64 (/ISA) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
1 | O17695 (/IPI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | G5ECH0 (/ISS) |
|
Histone deacetylase activity (H3-K9 specific) GO:0032129
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | O59702 (/NAS) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
1 | O59702 (/IMP) |
There are 65 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone H3 deacetylation GO:0070932
The modification of histone H3 by the removal of one or more acetyl groups.
|
10 | G5EB64 (/IMP) G5EB64 (/IMP) G5EB64 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Histone H4 deacetylation GO:0070933
The modification of histone H4 by the removal of one or more acetyl groups.
|
10 | G5EB64 (/IMP) G5EB64 (/IMP) G5EB64 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
9 | O17695 (/IMP) O59702 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
8 | O59702 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
8 | O17695 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
7 | P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
7 | P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) |
|
Regulation of transcription involved in G2/M transition of mitotic cell cycle GO:0000117
Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle.
|
7 | P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) P32561 (/IPI) |
|
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
7 | P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of transcription by RNA polymerase I GO:0016479
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
|
7 | P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of chromatin silencing at telomere GO:0031939
Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres.
|
7 | P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
|
Negative regulation of chromatin silencing at telomere GO:0031939
Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Protein localization to nucleolar rDNA repeats GO:0034503
Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of reciprocal meiotic recombination GO:0045128
Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) P32561 (/IGI) |
|
Negative regulation of transcription involved in meiotic cell cycle GO:0051038
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of chromatin silencing at silent mating-type cassette GO:0061186
Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Transfer RNA gene-mediated silencing GO:0061587
The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes.
|
7 | P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) P32561 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
4 | G5EB64 (/IDA) G5EB64 (/IDA) G5EB64 (/IDA) O17695 (/IDA) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
4 | O59702 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Vegetative to reproductive phase transition of meristem GO:0010228
The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Seed maturation GO:0010431
A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Posttranscriptional gene silencing GO:0016441
The inactivation of gene expression by a posttranscriptional mechanism.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
|
3 | Q9FML2 (/IMP) Q9FML2 (/IMP) Q9FML2 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
3 | G5EB64 (/ISA) G5EB64 (/ISA) G5EB64 (/ISA) |
|
DNA mediated transformation GO:0009294
The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material.
|
2 | O22446 (/IMP) O22446 (/IMP) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
2 | O22446 (/IMP) O22446 (/IMP) |
|
Jasmonic acid and ethylene-dependent systemic resistance GO:0009861
The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen.
|
2 | O22446 (/IMP) O22446 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
2 | O22446 (/IDA) O22446 (/IDA) |
|
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
|
2 | A0A1D8PSA6 (/IMP) Q5ADP0 (/IMP) |
|
Asexual sporulation resulting in formation of a cellular spore GO:0043936
The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
|
2 | Q4WI19 (/IMP) Q4WI19 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | O22446 (/IDA) O22446 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | O22446 (/IMP) O22446 (/IMP) |
|
Positive regulation of stem cell population maintenance GO:1902459
Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
|
2 | O22446 (/IGI) O22446 (/IGI) |
|
Regulation of multicellular organismal development GO:2000026
Any process that modulates the frequency, rate or extent of multicellular organismal development.
|
2 | O22446 (/IMP) O22446 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | G5ECH0 (/ISS) |
|
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
|
1 | G5ECH0 (/ISS) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | O59702 (/NAS) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | A0A1D8PSA6 (/IMP) |
|
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
|
1 | O17695 (/IMP) |
|
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | O17695 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | G5ECH0 (/ISS) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
1 | O17695 (/IMP) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | O17695 (/IMP) |
|
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
|
1 | O59702 (/IGI) |
|
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
|
1 | O59702 (/IMP) |
|
Negative regulation of vulval development GO:0040027
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | O17695 (/IGI) |
|
Negative regulation of vulval development GO:0040027
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | O17695 (/IMP) |
|
DNA protection GO:0042262
Any process in which DNA is protected from damage by, for example, oxidative stress.
|
1 | G5ECH0 (/IMP) |
|
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
|
1 | O17695 (/IMP) |
|
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
|
1 | O17695 (/IGI) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
1 | O17695 (/IMP) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
1 | O17695 (/IGI) |
|
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | O17695 (/IGI) |
|
Regulation of histone H3-K9 methylation GO:0051570
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
|
1 | O59702 (/NAS) |
|
Negative regulation of stress response to copper ion GO:1903854
Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion.
|
1 | O17695 (/IGI) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Rpd3S complex GO:0032221
A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).
|
8 | O59702 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
|
Rpd3L complex GO:0033698
A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
|
8 | O59702 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
|
Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
|
7 | P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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7 | G5ECH0 (/IDA) O17695 (/IDA) O22446 (/IDA) O22446 (/IDA) Q9FML2 (/IDA) Q9FML2 (/IDA) Q9FML2 (/IDA) |
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Rpd3L complex GO:0033698
A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
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7 | P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) |
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Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
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7 | P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
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Rpd3L-Expanded complex GO:0070210
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
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7 | P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) |
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Snt2C complex GO:0070211
A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p.
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7 | P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) P32561 (/HDA) |
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Sin3-type complex GO:0070822
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
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7 | P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) P32561 (/IDA) |
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Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
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3 | O17695 (/IPI) O22446 (/IPI) O22446 (/IPI) |
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Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
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3 | Q9FML2 (/IDA) Q9FML2 (/IDA) Q9FML2 (/IDA) |
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Histone deacetylase complex GO:0000118
A protein complex that possesses histone deacetylase activity.
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1 | G5ECH0 (/ISS) |
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Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
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1 | O59702 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | O17695 (/IDA) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | O59702 (/HDA) |
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NuRD complex GO:0016581
An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
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1 | O17695 (/IPI) |
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Germ cell nucleus GO:0043073
The nucleus of a germ cell, a reproductive cell in multicellular organisms.
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1 | O17695 (/IDA) |
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Rpd3L-Expanded complex GO:0070210
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
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1 | O59702 (/IDA) |
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Clr6 histone deacetylase complex I'' GO:1990483
A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.
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1 | O59702 (/IPI) |