The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alkaline Phosphatase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Alkaline phosphatase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
17 M9PD70 (/ISS) P09923 (/ISS) P09923 (/ISS) P19111 (/ISS) P24822 (/ISS) Q24238 (/ISS) Q7K3X8 (/ISS) Q9VDG4 (/ISS) Q9VHD0 (/ISS) Q9VIW9 (/ISS)
(7 more)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
16 A0A0G2JWW9 (/IDA) A0A0G2JZL2 (/IDA) M9PD70 (/IDA) P05187 (/IDA) P08289 (/IDA) P08289 (/IDA) P09242 (/IDA) P09487 (/IDA) P10696 (/IDA) P15693 (/IDA)
(6 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P05186 (/IPI) P05186 (/IPI) P05187 (/IPI) P09242 (/IPI) P09923 (/IPI) P09923 (/IPI) P15693 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
5 P05187 (/ISS) P09923 (/ISS) P09923 (/ISS) P19111 (/ISS) P24822 (/ISS)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
5 F8VPQ6 (/ISO) P09242 (/ISO) P24822 (/ISO) P24823 (/ISO) Q0VD75 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
5 P05187 (/ISS) P09923 (/ISS) P09923 (/ISS) P19111 (/ISS) P24822 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
4 A0A0G2JWW9 (/IDA) A0A0G2JZL2 (/IDA) P15693 (/IDA) Q9JKS8 (/IDA)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
4 P05187 (/NAS) P09923 (/NAS) P09923 (/NAS) P10696 (/NAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
4 A0A0G2JWW9 (/IDA) A0A0G2JZL2 (/IDA) P15693 (/IDA) Q9JKS8 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 F8VPQ6 (/ISO) P24822 (/ISO) Q0VD75 (/ISO)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
3 P08289 (/TAS) P08289 (/TAS) P15693 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 F8VPQ6 (/ISO) P24822 (/ISO) Q0VD75 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P09923 (/IPI) P09923 (/IPI)
Pyrophosphatase activity GO:0016462
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
2 P05186 (/IDA) P05186 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 F8VPQ6 (/ISO) Q0VD75 (/ISO)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P24822 (/ISO)
Pyrophosphatase activity GO:0016462
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
1 P09242 (/IMP)
Pyrophosphatase activity GO:0016462
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
1 P09242 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P15693 (/IPI)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
17 M9PD70 (/ISS) P09923 (/ISS) P09923 (/ISS) P19111 (/ISS) P24822 (/ISS) Q24238 (/ISS) Q7K3X8 (/ISS) Q9VDG4 (/ISS) Q9VHD0 (/ISS) Q9VIW9 (/ISS)
(7 more)
Phosphorus metabolic process GO:0006793
The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
4 A0A0G2JWW9 (/IDA) A0A0G2JZL2 (/IDA) P15693 (/IDA) Q9JKS8 (/IDA)
Phosphorus metabolic process GO:0006793
The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
3 F8VPQ6 (/ISO) P24822 (/ISO) Q0VD75 (/ISO)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
3 F8VPQ6 (/ISO) P09242 (/ISO) Q0VD75 (/ISO)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
3 A0A0G2JWW9 (/IEP) A0A0G2JZL2 (/IEP) Q9JKS8 (/IEP)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
2 P05186 (/TAS) P05186 (/TAS)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
2 P05186 (/HDA) P05186 (/HDA)
Phosphatidic acid biosynthetic process GO:0006654
The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
2 P09923 (/TAS) P09923 (/TAS)
Digestion GO:0007586
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
2 P09923 (/TAS) P09923 (/TAS)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
2 F1Q5B5 (/IDA) K4KG66 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
2 P15693 (/IDA) Q29486 (/IDA)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
2 P08289 (/IMP) P08289 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P08289 (/IEP) P08289 (/IEP)
Response to vitamin D GO:0033280
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
2 P05186 (/IEP) P05186 (/IEP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P08289 (/IDA) P08289 (/IDA)
Cementum mineralization GO:0071529
The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum.
2 P08289 (/IEP) P08289 (/IEP)
Cellular response to BMP stimulus GO:0071773
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus.
2 F8VPQ6 (/IDA) Q0VD75 (/IDA)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9VHD0 (/IMP)
Endochondral ossification GO:0001958
Replacement ossification wherein bone tissue replaces cartilage.
1 P09242 (/IMP)
Developmental process involved in reproduction GO:0003006
A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.
1 P09242 (/IGI)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q24238 (/IEP)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
1 P24822 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
1 P24822 (/IMP)
Biomineral tissue development GO:0031214
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
1 P09487 (/IDA)
Multicellular organism reproduction GO:0032504
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
1 Q24238 (/HEP)
Multicellular organism reproduction GO:0032504
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
1 Q24238 (/IEP)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 Q9VHD0 (/IEP)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 P24822 (/IMP)
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
1 P24822 (/IMP)
Epithelial fluid transport GO:0042045
The directed movement of fluid across epithelia.
1 Q24238 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P09242 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 P09242 (/ISO)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P09242 (/IDA)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
13 M9PD70 (/ISS) Q24238 (/ISS) Q7K3X8 (/ISS) Q9VDG4 (/ISS) Q9VHD0 (/ISS) Q9VIW9 (/ISS) Q9VP35 (/ISS) Q9VRM8 (/ISS) Q9VRM9 (/ISS) Q9VXS8 (/ISS)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 A0A024R4A2 (/IDA) A0A024R4A2 (/IDA) P05187 (/IDA) P08289 (/IDA) P08289 (/IDA) P09242 (/IDA) P09923 (/IDA) P09923 (/IDA) P10696 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
5 P05186 (/TAS) P05186 (/TAS) P09923 (/TAS) P09923 (/TAS) P10696 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 F8VPQ6 (/ISO) P09242 (/ISO) P24822 (/ISO) P24823 (/ISO) Q0VD75 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P05186 (/TAS) P05186 (/TAS) P09923 (/TAS) P09923 (/TAS) P10696 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
4 A0A0G2JWW9 (/IDA) A0A0G2JZL2 (/IDA) P15693 (/IDA) Q9JKS8 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 F8VPQ6 (/ISO) P24822 (/ISO) Q0VD75 (/ISO)
Extracellular membrane-bounded organelle GO:0065010
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
3 P09242 (/IDA) P09487 (/IDA) Q92058 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P08289 (/IDA) P08289 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 F8VPQ6 (/ISO) Q0VD75 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P05186 (/HDA) P05186 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P05186 (/HDA) P05186 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q24238 (/ISM)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q24238 (/ISM)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P09242 (/ISO)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 P24822 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P05187 (/IDA)
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
1 P24823 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P09242 (/IDA)
Anchored component of plasma membrane GO:0046658
The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
1 Q29486 (/IDA)
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