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CATH Superfamily 3.40.720.10

Alkaline Phosphatase, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alkaline Phosphatase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Arylsulfatase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Arylsulfatase (type I). [EC: 3.1.6.1]
A phenol sulfate + H(2)O = a phenol + sulfate.
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities.
  • The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate.
  • This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.-, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.-, cysteine-type anaerobic sulfatase-maturating enzyme.
 25 A0A0F6RP95 A0A0F6RP95 A0A0F6RP95 A0A0F6RP95 A0A0F6RP95 A0A1S1BX97 A0A1S1BX97 A0A1S1BX97 A0A1S1BX97 A0A1S1BX97
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