The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 46: Cystathionine gamma-lyase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cysteine-S-conjugate beta-lyase activity GO:0047804
Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.
4 P43623 (/IDA) P43623 (/IDA) P43623 (/IDA) P43623 (/IDA)
Cysteine-S-conjugate beta-lyase activity GO:0047804
Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate.
4 P43623 (/IMP) P43623 (/IMP) P43623 (/IMP) P43623 (/IMP)
Cystathionine gamma-lyase activity GO:0004123
Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.
1 E9AFE7 (/TAS)
Methionine gamma-lyase activity GO:0018826
Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate.
1 Q9SGU9 (/IDA)
Methionine gamma-lyase activity GO:0018826
Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate.
1 Q5MQ31 (/IMP)
D-cysteine desulfhydrase activity GO:0019148
Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate.
1 Q4Q511 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sulfur compound metabolic process GO:0006790
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
4 P43623 (/IDA) P43623 (/IDA) P43623 (/IDA) P43623 (/IDA)
Sulfur compound metabolic process GO:0006790
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
4 P43623 (/IMP) P43623 (/IMP) P43623 (/IMP) P43623 (/IMP)
L-cysteine catabolic process to pyruvate GO:0019450
The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.
4 P43623 (/IDA) P43623 (/IDA) P43623 (/IDA) P43623 (/IDA)
L-cysteine catabolic process to pyruvate GO:0019450
The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.
4 P43623 (/IMP) P43623 (/IMP) P43623 (/IMP) P43623 (/IMP)
Replication-born double-strand break repair via sister chromatid exchange GO:1990414
The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks.
4 P43623 (/IMP) P43623 (/IMP) P43623 (/IMP) P43623 (/IMP)
Cysteine catabolic process GO:0009093
The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.
1 Q4Q511 (/IDA)
Cellular response to sulfate starvation GO:0009970
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.
1 Q9SGU9 (/IEP)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
1 Q38DH3 (/IDA)
Methionine catabolic process via 2-oxobutanoate GO:0019458
The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate.
1 Q9SGU9 (/TAS)
S-adenosylhomocysteine catabolic process GO:0019510
The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.
1 E9AFE7 (/TAS)
Cellular response to water deprivation GO:0042631
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.
1 Q9SGU9 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q9SGU9 (/IDA)
Hydrogen sulfide biosynthetic process GO:0070814
The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
1 Q4Q511 (/IDA)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q38DH3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9AFE7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9SGU9 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 Q38DH3 (/IDA)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
1 E9AFE7 (/ISO)
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