The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Aldehyde dehydrogenase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 46 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
37 P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA)
(27 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
30 P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P05091 (/IDA) P05091 (/IDA) P05091 (/IDA) P11884 (/IDA) P13601 (/IDA) P37685 (/IDA) P37685 (/IDA)
(20 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
20 P15437 (/ISS) P24549 (/ISS) P27463 (/ISS) P86886 (/ISS) P86886 (/ISS) Q54IU0 (/ISS) Q54QC5 (/ISS) Q880T7 (/ISS) Q880T7 (/ISS) Q880T7 (/ISS)
(10 more)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
19 O93344 (/ISS) O93344 (/ISS) O94788 (/ISS) P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P24549 (/ISS) P27463 (/ISS) P51977 (/ISS)
(9 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
19 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P05091 (/ISS) P05091 (/ISS) P05091 (/ISS) P12762 (/ISS) P13601 (/ISS) P15437 (/ISS) P20000 (/ISS)
(9 more)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
14 P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA)
(4 more)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
11 O94788 (/IDA) P47895 (/IDA) P47895 (/IDA) P48644 (/IDA) P51647 (/IDA) Q28399 (/IDA) Q62148 (/IDA) Q63639 (/IDA) Q8BH00 (/IDA) Q8HYE4 (/IDA)
(1 more)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
10 P08157 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
8 P11884 (/IDA) P13601 (/IDA) P51647 (/IDA) P77674 (/IDA) P77674 (/IDA) P77674 (/IDA) P77674 (/IDA) P77674 (/IDA)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
6 A2BGR9 (/IDA) P13601 (/IDA) P24549 (/IDA) Q62148 (/IDA) Q7SXU3 (/IDA) Q8QGQ2 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
6 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
5 P24549 (/ISO) Q62148 (/ISO) Q8BH00 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Aminobutyraldehyde dehydrogenase activity GO:0019145
Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.
5 P77674 (/IDA) P77674 (/IDA) P77674 (/IDA) P77674 (/IDA) P77674 (/IDA)
1-pyrroline dehydrogenase activity GO:0033737
Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+.
5 P77674 (/IMP) P77674 (/IMP) P77674 (/IMP) P77674 (/IMP) P77674 (/IMP)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
4 P13601 (/TAS) P51647 (/TAS) Q9JHW9 (/TAS) Q9JHW9 (/TAS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
4 A0A1D8PSW6 (/IMP) P08157 (/IMP) P11884 (/IMP) P47771 (/IMP)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
3 P24549 (/ISO) P47738 (/ISO) P47738 (/ISO)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
3 P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS)
Androgen binding GO:0005497
Interacting selectively and non-covalently with any androgen, male sex hormones.
3 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P11884 (/IPI) P47738 (/IPI) P47738 (/IPI)
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
3 P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P24549 (/ISO) P47738 (/ISO) P47738 (/ISO)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
2 Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Retinol dehydrogenase activity GO:0004745
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
2 O93344 (/IDA) O93344 (/IDA)
Benzaldehyde dehydrogenase (NAD+) activity GO:0018479
Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+.
2 P13601 (/IDA) P51647 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P47895 (/IDA) P47895 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Thyroid hormone binding GO:0070324
Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.
2 Q9JHW9 (/IPI) Q9JHW9 (/IPI)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
2 Q9JHW9 (/IDA) Q9JHW9 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
2 P47738 (/ISO) P47738 (/ISO)
Retinal dehydrogenase activity GO:0001758
Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.
1 Q9H2A2 (/TAS)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
1 Q9URW9 (/ISO)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
1 O94788 (/ISS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
1 P08157 (/RCA)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
1 P08157 (/RCA)
Acetaldehyde dehydrogenase (acetylating) activity GO:0008774
Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.
1 Q9VLC5 (/IDA)
Lactaldehyde dehydrogenase activity GO:0008911
Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+.
1 P08157 (/RCA)
Retinal binding GO:0016918
Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
1 Q63639 (/IDA)
Retinal binding GO:0016918
Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
1 Q62148 (/ISO)
Retinal binding GO:0016918
Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina.
1 O94788 (/ISS)
Benzaldehyde dehydrogenase (NAD+) activity GO:0018479
Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+.
1 P24549 (/ISO)
Fluoroacetaldehyde dehydrogenase activity GO:0033723
Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+.
1 F8JX40 (/IDA)
Long-chain-aldehyde dehydrogenase activity GO:0050061
Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons.
1 Q9FDS1 (/IDA)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
1 Q28399 (/IDA)
NADH binding GO:0070404
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
1 P11884 (/IDA)

There are 175 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Putrescine catabolic process GO:0009447
The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
28 P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP)
(18 more)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
15 P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA) P37685 (/IDA)
(5 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
14 P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP) P37685 (/IEP)
(4 more)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
11 Q880T7 (/ISS) Q880T7 (/ISS) Q880T7 (/ISS) Q88BC5 (/ISS) Q88BC5 (/ISS) Q88BC5 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS) Q9KR28 (/ISS)
(1 more)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
10 P08157 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
9 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P27463 (/ISS) P51977 (/ISS) P86886 (/ISS) P86886 (/ISS) Q8MI17 (/ISS)
NADPH regeneration GO:0006740
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
9 P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
9 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Negative regulation by symbiont of host immune response GO:0052562
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction.
9 P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA) P9WNY1 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
8 F8JX40 (/IDA) O94788 (/IDA) P13601 (/IDA) P47895 (/IDA) P47895 (/IDA) P51647 (/IDA) Q28399 (/IDA) Q9FDS1 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
8 O93344 (/ISS) O93344 (/ISS) Q62148 (/ISS) Q63639 (/ISS) Q8K4D8 (/ISS) Q9I8W8 (/ISS) Q9JHW9 (/ISS) Q9JHW9 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
8 P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P48644 (/IDA) P51647 (/IDA) P51977 (/IDA) Q8HYE4 (/IDA) Q8MI17 (/IDA)
Ethanol oxidation GO:0006069
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.
7 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P05091 (/TAS) P05091 (/TAS) P05091 (/TAS) P30837 (/TAS)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
6 B3DKM0 (/IMP) Q66I21 (/IMP) Q66I21 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
6 P24549 (/IDA) P47895 (/IDA) P47895 (/IDA) Q62148 (/IDA) Q63639 (/IDA) Q9H2A2 (/IDA)
Retinoic acid biosynthetic process GO:0002138
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
5 O94788 (/IDA) P47895 (/IDA) P47895 (/IDA) Q9JHW9 (/IDA) Q9JHW9 (/IDA)
Retinoic acid biosynthetic process GO:0002138
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
5 P51647 (/IMP) Q63639 (/IMP) Q8K4D8 (/IMP) Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Retinoic acid biosynthetic process GO:0002138
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
5 O93344 (/ISS) O93344 (/ISS) Q63639 (/ISS) Q8K4D8 (/ISS) Q9I8W8 (/ISS)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
5 B3DKM0 (/IMP) Q62148 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Pancreas development GO:0031016
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
5 B3DKM0 (/IMP) Q62148 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
5 P47895 (/IDA) P47895 (/IDA) Q28399 (/IDA) Q62148 (/IDA) Q9H2A2 (/IDA)
Retinoic acid receptor signaling pathway GO:0048384
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.
5 B3DKM0 (/IMP) Q62148 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
5 A0A0H2UHP1 (/ISS) P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P51647 (/ISS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 B3DKM0 (/IGI) Q8QGQ1 (/IGI) Q90XS8 (/IGI) Q90Y03 (/IGI)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Retinoic acid biosynthetic process GO:0002138
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
4 P24549 (/ISO) Q62148 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Determination of left/right symmetry GO:0007368
The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Hindbrain morphogenesis GO:0021575
The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Central nervous system myelination GO:0022010
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Pectoral fin development GO:0033339
The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
4 B3DKM0 (/IGI) Q8QGQ1 (/IGI) Q90XS8 (/IGI) Q90Y03 (/IGI)
Pronephric duct morphogenesis GO:0039023
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
4 B3DKM0 (/IGI) Q8QGQ1 (/IGI) Q90XS8 (/IGI) Q90Y03 (/IGI)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
4 P24549 (/IMP) Q62148 (/IMP) Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
4 Q62148 (/ISO) Q8BH00 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Axial mesoderm development GO:0048318
The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Paraxial mesoderm development GO:0048339
The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Regulation of retinoic acid receptor signaling pathway GO:0048385
Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Digestive tract morphogenesis GO:0048546
The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Pronephros development GO:0048793
The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
4 P24549 (/ISO) Q62148 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
4 P15437 (/ISS) P27463 (/ISS) P86886 (/ISS) P86886 (/ISS)
Face morphogenesis GO:0060325
The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Pancreas field specification GO:0061131
The process in which a specific region of the gut is delineated into the area in which the pancreas will develop.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
4 B3DKM0 (/IMP) Q8QGQ1 (/IMP) Q90XS8 (/IMP) Q90Y03 (/IMP)
Regulation of cellular response to drug GO:2001038
Any process that modulates the frequency, rate or extent of cellular response to drug.
4 F1QZU7 (/IMP) Q1JPX8 (/IMP) Q32PU9 (/IMP) Q6TH48 (/IMP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
3 P48644 (/IDA) P51647 (/IDA) Q8HYE4 (/IDA)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
3 P51647 (/IEP) Q63639 (/IEP) Q8K4D8 (/IEP)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
3 P11884 (/IEP) P51647 (/IEP) Q63639 (/IEP)
Optic cup morphogenesis involved in camera-type eye development GO:0002072
The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.
3 P24549 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
3 O93344 (/IMP) O93344 (/IMP) Q62148 (/IMP)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
3 P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
Alcohol metabolic process GO:0006066
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
3 P05091 (/TAS) P05091 (/TAS) P05091 (/TAS)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
3 A2BGR9 (/ISS) Q7SXU3 (/ISS) Q8QGQ2 (/ISS)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
3 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS)
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
3 Q62148 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
3 P11884 (/IEP) P51647 (/IEP) Q63639 (/IEP)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
3 P24549 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
3 O94788 (/ISS) Q0P5F9 (/ISS) Q8BH00 (/ISS)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
3 Q8BH00 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
9-cis-retinoic acid biosynthetic process GO:0042904
The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative.
3 P24549 (/IDA) Q62148 (/IDA) Q8BH00 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 P24549 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 Q62148 (/IMP) Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
3 P24549 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Face development GO:0060324
The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.
3 Q62148 (/IGI) Q9JHW9 (/IGI) Q9JHW9 (/IGI)
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:0061624
The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.
3 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
2 O93344 (/IMP) O93344 (/IMP)
Retinoic acid biosynthetic process GO:0002138
The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
2 Q63639 (/IEP) Q8K4D8 (/IEP)
Polyamine catabolic process GO:0006598
The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
2 P47771 (/IMP) P54114 (/IMP)
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
2 P51647 (/IEP) Q63639 (/IEP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O93344 (/IEP) O93344 (/IEP)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
2 P47771 (/IMP) P54114 (/IMP)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2 O93344 (/IEP) O93344 (/IEP)
Nucleus accumbens development GO:0021768
The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Pituitary gland development GO:0021983
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
2 Q63639 (/IEP) Q8K4D8 (/IEP)
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Embryonic camera-type eye development GO:0031076
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
2 P47895 (/ISS) P47895 (/ISS)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P51647 (/IEP) Q8K4D8 (/IEP)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
2 Q0P5F9 (/ISS) Q8BH00 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P47738 (/ISO) P47738 (/ISO)
Nose development GO:0043584
The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
2 P47895 (/ISS) P47895 (/ISS)
Positive regulation of retinoic acid receptor signaling pathway GO:0048386
Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
2 Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Neuromuscular process controlling balance GO:0050885
Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Olfactory pit development GO:0060166
The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Harderian gland development GO:0070384
The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species.
2 Q9JHW9 (/IMP) Q9JHW9 (/IMP)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 P24549 (/ISO)
Retinoid metabolic process GO:0001523
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
1 Q62148 (/TAS)
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
1 Q62148 (/IMP)
Regulation of endothelial cell proliferation GO:0001936
Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.
1 Q62148 (/IMP)
Heart looping GO:0001947
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
1 Q62148 (/TAS)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
1 P30837 (/NAS)
Ethanol metabolic process GO:0006067
The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.
1 P08157 (/IMP)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
1 Q9URW9 (/IC)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
1 P08157 (/RCA)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
1 Q9VLC5 (/ISS)
Acetaldehyde metabolic process GO:0006117
The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
1 Q9VLC5 (/IMP)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 P08157 (/IEP)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 P08157 (/IMP)
Polyamine catabolic process GO:0006598
The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
1 Q9URW9 (/ISO)
Vitamin A metabolic process GO:0006776
The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.
1 O94788 (/NAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P51647 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P24549 (/ISO)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q62148 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q62148 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O94788 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q62148 (/ISO)
Methylglyoxal metabolic process GO:0009438
The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
1 P08157 (/RCA)
Determination of bilateral symmetry GO:0009855
The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
1 Q62148 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q62148 (/IGI)
Proximal/distal pattern formation GO:0009954
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end).
1 Q62148 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q62148 (/IMP)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 Q62148 (/IGI)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 Q62148 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P51647 (/IEP)
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
1 Q62148 (/IMP)
Beta-alanine metabolic process GO:0019482
The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
1 P08157 (/RCA)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
1 Q9URW9 (/ISO)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
1 O94788 (/IMP)
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
1 Q62148 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q62148 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 Q62148 (/IMP)
Embryonic limb morphogenesis GO:0030326
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.
1 Q62148 (/IMP)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 Q62148 (/IMP)
Hindbrain development GO:0030902
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).
1 Q62148 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P11884 (/IEP)
Response to retinoic acid GO:0032526
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 P51647 (/IEP)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 P11884 (/IEP)
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P11884 (/IEP)
Response to vitamin A GO:0033189
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
1 Q63639 (/IEP)
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
1 P11884 (/IEP)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 O94788 (/IDA)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 Q62148 (/ISO)
Response to nicotine GO:0035094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
1 P11884 (/IEP)
Operant conditioning GO:0035106
Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior.
1 P13601 (/IEP)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 Q62148 (/IMP)
Ureter maturation GO:0035799
A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.
1 Q62148 (/IMP)
Penicillin biosynthetic process GO:0042318
The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.
1 P08157 (/RCA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P24549 (/IDA)
Retinol metabolic process GO:0042572
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
1 P24549 (/IMP)
Retinoic acid metabolic process GO:0042573
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
1 Q63639 (/TAS)
Retinal metabolic process GO:0042574
The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.
1 Q8BH00 (/IC)
9-cis-retinoic acid metabolic process GO:0042905
The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative.
1 P51647 (/IDA)
9-cis-retinoic acid metabolic process GO:0042905
The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative.
1 P24549 (/ISO)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 Q62148 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P11884 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 P51647 (/IEP)
Carnitine biosynthetic process GO:0045329
The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
1 A0A1D8PSW6 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 Q9VLC5 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P24549 (/ISO)
Carbon catabolite activation of transcription GO:0045991
A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources.
1 P08157 (/IMP)
Acetaldehyde catabolic process GO:0046187
The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
1 P08157 (/IEP)
Acetaldehyde catabolic process GO:0046187
The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol.
1 P08157 (/IMP)
Retinoic acid receptor signaling pathway GO:0048384
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.
1 Q62148 (/IGI)
Positive regulation of retinoic acid receptor signaling pathway GO:0048386
Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity.
1 Q9DD46 (/IDA)
Embryonic digestive tract development GO:0048566
The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.
1 Q62148 (/IMP)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
1 Q62148 (/IMP)
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
1 P11884 (/IEP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P24549 (/ISO)
Face development GO:0060324
The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.
1 Q62148 (/IMP)
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
1 Q62148 (/IEP)
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
1 P11884 (/IEP)
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 P08157 (/IEP)
Retinoic acid receptor signaling pathway involved in somitogenesis GO:0090242
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis.
1 Q62148 (/IGI)
Retinoic acid receptor signaling pathway involved in somitogenesis GO:0090242
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis.
1 Q62148 (/IMP)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 P24549 (/IMP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q9VLC5 (/IMP)

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
27 A0A024RC95 (/IDA) A0A024RC95 (/IDA) P00352 (/IDA) P00352 (/IDA) P00352 (/IDA) P47895 (/IDA) P47895 (/IDA) P48644 (/IDA) P54115 (/IDA) P54115 (/IDA)
(17 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
13 P47738 (/HDA) P47738 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA)
(3 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
12 P11884 (/IDA) P30837 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P00352 (/ISS) P00352 (/ISS) P00352 (/ISS) P15437 (/ISS) P24549 (/ISS) P27463 (/ISS) P51647 (/ISS) P51977 (/ISS) P86886 (/ISS) P86886 (/ISS)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA) P9WNY1 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
9 P00352 (/HDA) P00352 (/HDA) P00352 (/HDA) P05091 (/HDA) P05091 (/HDA) P05091 (/HDA) P47895 (/HDA) P47895 (/HDA) Q9H2A2 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 O94788 (/IDA) P47895 (/IDA) P47895 (/IDA) P51647 (/IDA) Q9JHW9 (/IDA) Q9JHW9 (/IDA) Q9VLC5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 O94788 (/TAS) P00352 (/TAS) P00352 (/TAS) P00352 (/TAS) P47895 (/TAS) P47895 (/TAS) Q9H2A2 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 A0A024RC95 (/IDA) A0A024RC95 (/IDA) P47895 (/IDA) P47895 (/IDA) P51647 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P24549 (/ISO) Q62148 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
4 P05091 (/TAS) P05091 (/TAS) P05091 (/TAS) P30837 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P24549 (/ISO) Q62148 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A024RC95 (/IDA) A0A024RC95 (/IDA) P47895 (/IDA) P47895 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P24549 (/ISO) Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P00352 (/TAS) P00352 (/TAS) P00352 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P47738 (/ISO) P47738 (/ISO) Q9CZS1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P13601 (/NAS) Q8K4D8 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9JHW9 (/ISO) Q9JHW9 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P08157 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9URW9 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P30837 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9CZS1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P47771 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P54114 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9VLC5 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9URW9 (/HDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P30837 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9CZS1 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q63639 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q62148 (/ISO)