The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Ubiquitin carboxyl-terminal hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
7 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) Q9R0P9 (/IDA) Q9R0P9 (/IDA)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
7 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) Q9R0P9 (/IDA) Q9R0P9 (/IDA)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
5 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI)
Omega peptidase activity GO:0008242
Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).
5 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
5 P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI)
Alpha-2A adrenergic receptor binding GO:0031694
Interacting selectively and non-covalently with an alpha-2A adrenergic receptor.
5 P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI) P09936 (/IPI)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
5 P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Cysteine-type endopeptidase activity GO:0004197
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2 Q9R0P9 (/ISS) Q9R0P9 (/ISS)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Omega peptidase activity GO:0008242
Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Omega peptidase activity GO:0008242
Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).
2 Q9R0P9 (/ISS) Q9R0P9 (/ISS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Alpha-2A adrenergic receptor binding GO:0031694
Interacting selectively and non-covalently with an alpha-2A adrenergic receptor.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
2 Q9R0P9 (/ISS) Q9R0P9 (/ISS)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
5 P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
5 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
5 P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
5 P09936 (/NAS) P09936 (/NAS) P09936 (/NAS) P09936 (/NAS) P09936 (/NAS)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
5 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
2 Q00981 (/IDA) Q00981 (/IDA)
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Axon target recognition GO:0007412
The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 Q9R0P9 (/IGI) Q9R0P9 (/IGI)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 Q9R0P9 (/ISS) Q9R0P9 (/ISS)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 Q00981 (/IDA) Q00981 (/IDA)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)
Eating behavior GO:0042755
The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
2 Q9R0P9 (/IGI) Q9R0P9 (/IGI)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
2 Q9R0P9 (/IGI) Q9R0P9 (/IGI)
Neuromuscular process GO:0050905
Any process pertaining to the functions of the nervous and muscular systems of an organism.
2 Q9R0P9 (/IMP) Q9R0P9 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 D6R956 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
(7 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
15 D6R956 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) D6RE83 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA)
(5 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) P09936 (/IDA) Q9R0P9 (/IDA) Q9R0P9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P09936 (/ISS) P09936 (/ISS) P09936 (/ISS) P09936 (/ISS) P09936 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS) P09936 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9R0P9 (/ISO) Q9R0P9 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q9R0P9 (/IDA) Q9R0P9 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9R0P9 (/IDA) Q9R0P9 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 Q9R0P9 (/HDA) Q9R0P9 (/HDA)
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
2 Q9R0P9 (/IDA) Q9R0P9 (/IDA)
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