The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Ubiquitin carboxyl-terminal hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
2 O04482 (/IDA) O04482 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O04482 (/IPI) O04482 (/IPI)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q9UUB6 (/HDA)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 Q9UUB6 (/IGI)
NEDD8-specific protease activity GO:0019784
Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates.
1 Q9UUB6 (/IDA)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Shoot system morphogenesis GO:0010016
The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground.
3 O04482 (/IGI) O04482 (/IGI) Q9FFF2 (/IGI)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
2 O04482 (/IDA) O04482 (/IDA)
Protein deneddylation GO:0000338
The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
1 Q9UUB6 (/IDA)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q9UUB6 (/HDA)
Cytoplasm protein quality control by the ubiquitin-proteasome system GO:0071629
The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
1 Q9UUB6 (/IGI)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O04482 (/IDA) O04482 (/IDA) Q9FFF2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O04482 (/IDA) O04482 (/IDA) Q9FFF2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UUB6 (/HDA)
Nuclear proteasome complex GO:0031595
A proteasome found in the nucleus of a cell.
1 Q9UUB6 (/HDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 Q9UUB6 (/HDA)
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