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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 43: Ketol-acid reductoisomerase (NADP(+))

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 33 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(23 more)
Ketol-acid reductoisomerase activity GO:0004455
Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
 33 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(23 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 20 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(10 more)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
 20 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(10 more)
Ketol-acid reductoisomerase activity GO:0004455
Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.
 8 Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 20 P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP)
(10 more)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
 20 P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP) P05793 (/IMP)
(10 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
 20 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(10 more)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
 8 Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS)
Valine biosynthetic process GO:0009099
The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.
 8 Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS) Q9KVI4 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 20 P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA) P05793 (/IDA)
(10 more)