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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 164: Carbonyl reductase [NADPH] 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 48 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53
(38 more...)
Prostaglandin-E(2) 9-reductase. [EC: 1.1.1.189]
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
  • Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.
  • A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.
  • May be identical with EC 1.1.1.197.
 38 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53
(28 more...)
15-hydroxyprostaglandin dehydrogenase (NADP(+)). [EC: 1.1.1.197]
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
  • Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196).
  • May be identical with EC 1.1.1.189.
 38 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A2R9ARG9 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53 A0A384NL53
(28 more...)
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