The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 803: Ras-related protein Rab-43

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
19 O18339 (/IPI) O18339 (/IPI) O18339 (/IPI) O18339 (/IPI) Q86YS6 (/IPI) Q86YS6 (/IPI) Q86YS6 (/IPI) Q86YS6 (/IPI) Q86YS6 (/IPI) Q86YS6 (/IPI)
(9 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
14 Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA)
(4 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
7 O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
4 O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) O18339 (/ISS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
14 Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP)
(4 more)
Virion assembly GO:0019068
A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.
14 Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP)
(4 more)
Retrograde transport, plasma membrane to Golgi GO:0035526
The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.
14 Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP)
(4 more)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
14 Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP) Q86YS6 (/IMP)
(4 more)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
4 O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) O18339 (/ISS)
Rab protein signal transduction GO:0032482
A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.
4 O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) O18339 (/ISS)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
4 O18339 (/IGI) O18339 (/IGI) O18339 (/IGI) O18339 (/IGI)
Enteroendocrine cell differentiation GO:0035883
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.
4 O18339 (/IMP) O18339 (/IMP) O18339 (/IMP) O18339 (/IMP)
Regulation of cell differentiation involved in tissue homeostasis GO:0060786
Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.
4 O18339 (/IMP) O18339 (/IMP) O18339 (/IMP) O18339 (/IMP)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
3 Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
Retrograde transport, plasma membrane to Golgi GO:0035526
The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.
3 Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
3 Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)
Virion assembly GO:0019068
A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)
Retrograde transport, plasma membrane to Golgi GO:0035526
The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
2 Q8CG50 (/IDA) Q8CG50 (/IDA)
Phagosome maturation GO:0090382
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q8CG50 (/IMP) Q8CG50 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
18 O18339 (/IDA) O18339 (/IDA) O18339 (/IDA) O18339 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA)
(8 more)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
16 Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA) Q86YS6 (/IDA)
(6 more)
Trans-Golgi network membrane GO:0032588
The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.
14 Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS) Q86YS6 (/TAS)
(4 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
14 Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA) Q86YS6 (/HDA)
(4 more)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 O18339 (/ISS) O18339 (/ISS) O18339 (/ISS) O18339 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 O18339 (/IDA) O18339 (/IDA) O18339 (/IDA) O18339 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 O18339 (/HDA) O18339 (/HDA) O18339 (/HDA) O18339 (/HDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 O18339 (/IDA) O18339 (/IDA) O18339 (/IDA) O18339 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
4 O18339 (/HDA) O18339 (/HDA) O18339 (/HDA) O18339 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
3 Q53B90 (/ISS) Q8CG50 (/ISS) Q8CG50 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
2 Q8CG50 (/ISO) Q8CG50 (/ISO)