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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 450: ABC transporter C family member 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ABC-type xenobiotic transporter. [EC: 7.6.2.2]
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1).
  • Formerly EC 3.6.3.44.
 7 A0A178WBV0 A0A178WBV0 Q42093 Q9C8G9 Q9C8G9 Q9C8H0 Q9C8H1
ABC-type glutathione-S-conjugate transporter. [EC: 7.6.2.3]
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2).
  • A eukaryotic ATP-binding cassette (ABC) type transporter that mediates the transport of glutathione-S-conjugates.
  • The mammalian enzyme, which also transports some glucuronides, exports the substrates out of the cell, while plant and fungal transporters export them into the vacuole.
  • Over-expression confers resistance to anticancer drugs by their efficient exportation in glutathione-S-conjugate form.
 1 P39109
ABC-type Cd(2+) transporter. [EC: 7.2.2.2]
ATP + H(2)O + Cd(2+)(Side 1) = ADP + phosphate + Cd(2+)(Side 2).
  • A Saccharomyces cerevisiae enzyme that exports some heavy metals, especially Cd(2+), from the cytosol into the vacuole.
  • Formerly EC 3.6.3.46.
 1 P39109