The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 438: Rho-related GTP-binding protein RhoJ

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
43 Q8R527 (/IPI) Q8R527 (/IPI) Q8R527 (/IPI) Q8R527 (/IPI) Q9ER71 (/IPI) Q9H4E5 (/IPI) Q9H4E5 (/IPI) Q9H4E5 (/IPI) Q9H4E5 (/IPI) Q9H4E5 (/IPI)
(33 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
38 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(28 more)
Profilin binding GO:0005522
Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
31 P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI)
(21 more)
GBD domain binding GO:0032427
Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.
31 P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI) P17081 (/IPI)
(21 more)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
7 Q9H4E5 (/NAS) Q9H4E5 (/NAS) Q9H4E5 (/NAS) Q9H4E5 (/NAS) Q9H4E5 (/NAS) Q9H4E5 (/NAS) Q9H4E5 (/NAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
7 Q9H4E5 (/IDA) Q9H4E5 (/IDA) Q9H4E5 (/IDA) Q9H4E5 (/IDA) Q9H4E5 (/IDA) Q9H4E5 (/IDA) Q9H4E5 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
5 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q9ER71 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
4 Q8R527 (/TAS) Q8R527 (/TAS) Q8R527 (/TAS) Q8R527 (/TAS)
Profilin binding GO:0005522
Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
GBD domain binding GO:0032427
Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q9ER71 (/ISS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q9ER71 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q9ER71 (/ISS)

There are 35 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
38 P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS)
(28 more)
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
35 P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP)
(25 more)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
35 P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP)
(25 more)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
31 P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP)
(21 more)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
31 P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC) P17081 (/IC)
(21 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
31 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(21 more)
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
31 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(21 more)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
31 P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP)
(21 more)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
31 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(21 more)
Negative regulation of protein localization to plasma membrane GO:1903077
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
31 P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP) P17081 (/IMP)
(21 more)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
7 Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
7 Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
7 Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP)
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
7 Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP) Q9H4E5 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
5 Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA) Q9ER71 (/IDA)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
4 Q8R527 (/TAS) Q8R527 (/TAS) Q8R527 (/TAS) Q8R527 (/TAS)
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
GTP metabolic process GO:0046039
The chemical reactions and pathways involving GTP, guanosine triphosphate.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
4 Q8R527 (/IC) Q8R527 (/IC) Q8R527 (/IC) Q8R527 (/IC)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Negative regulation of protein localization to plasma membrane GO:1903077
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
4 Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA)
Negative regulation of protein localization to plasma membrane GO:1903077
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
1 Q9ER71 (/IDA)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 Q9ER71 (/ISO)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 Q9ER71 (/ISS)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9ER71 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9ER71 (/ISO)
Retina vasculature morphogenesis in camera-type eye GO:0061299
The process in which the vasculature of the retina is generated and organized.
1 Q9ER71 (/IMP)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
1 Q9ER71 (/ISO)
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
1 Q9ER71 (/ISO)
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
1 Q9ER71 (/ISS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
42 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(32 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
38 P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS)
(28 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
38 P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS)
(28 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
38 P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA) P17081 (/HDA)
(28 more)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
31 P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA) P17081 (/IDA)
(21 more)
Golgi-associated vesicle membrane GO:0030660
The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.
31 P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS) P17081 (/TAS)
(21 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q9ER71 (/ISO)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
4 Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO) Q8R527 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
4 Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA) Q8R527 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9ER71 (/ISS)
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