The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 263: Ras-related protein RABB1c

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
7 O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) Q9U5D5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O18333 (/IPI) O18333 (/IPI) O18333 (/IPI) O18333 (/IPI) O18333 (/IPI) O18333 (/IPI) Q9U5D5 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 Q381R1 (/ISM) Q381R1 (/ISM)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q38922 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
12 Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS) Q8I5A9 (/ISS)
(2 more)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
7 O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) Q9U5D5 (/ISS)
Rab protein signal transduction GO:0032482
A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.
7 O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) Q9U5D5 (/ISS)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
6 O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP)
Regulation of glutamate receptor clustering GO:0106104
Any process that modulates the frequency, rate or extent of glutamate receptor clustering.
6 O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP) O18333 (/IMP)
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
5 P92963 (/TAS) P92963 (/TAS) P92963 (/TAS) P92963 (/TAS) P92963 (/TAS)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
2 Q381R1 (/ISM) Q381R1 (/ISM)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P36409 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 P36409 (/IMP)
Cell death GO:0008219
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
1 P36409 (/IMP)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 P36409 (/IMP)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
17 P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) Q8I5A9 (/IDA) Q8I5A9 (/IDA) Q8I5A9 (/IDA) Q8I5A9 (/IDA) Q8I5A9 (/IDA)
(7 more)
Food vacuole GO:0020020
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
12 Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA) Q8I5A9 (/RCA)
(2 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
7 O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) Q9U5D5 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) Q9U5D5 (/HDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
7 O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) O18333 (/ISS) Q9U5D5 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
7 O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) O18333 (/HDA) Q9U5D5 (/HDA)
Type II terminal bouton GO:0061175
Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
6 O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA)
Postsynapse of neuromuscular junction GO:0098975
The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.
6 O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA) O18333 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA) P92963 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
2 Q381R1 (/IDA) Q381R1 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 P36409 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
1 P36409 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q38922 (/IDA)
Contractile vacuolar membrane GO:0031164
The lipid bilayer surrounding the contractile vacuole.
1 P36409 (/IDA)
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