View in Gene3D

CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2556: Pentafunctional AROM polypeptide

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-dehydroquinate dehydratase. [EC: 4.2.1.10]
3-dehydroquinate = 3-dehydroshikimate + H(2)O.
    		 4 P0CM22 P0CM22 P0CM23 P0CM23
    Shikimate dehydrogenase. [EC: 1.1.1.25]
    Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
    • NAD(+) cannot replace NADP(+).
    • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
    		 4 P0CM22 P0CM22 P0CM23 P0CM23
    3-dehydroquinate synthase. [EC: 4.2.3.4]
    3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
    • The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products.
    • Formerly EC 4.6.1.3.
    		 4 P0CM22 P0CM22 P0CM23 P0CM23
    3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
      		 4 P0CM22 P0CM22 P0CM23 P0CM23
      Shikimate kinase. [EC: 2.7.1.71]
      ATP + shikimate = ADP + shikimate 3-phosphate.
        		 4 P0CM22 P0CM22 P0CM23 P0CM23
        CATH-Gene3D is a Global Biodata Core Resource Learn more...