The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase S8/S53 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Furin 2, isoform BProprotein convertase subtilisin/kexin type 7Proteinase KSubtilisin-like protease 1SC:2Tripeptidyl peptidase 2Tripeptidyl-peptidase 1 preproproteinIntracellular serine proteaseType VII secretion-associated serine protease mycosinSubtilisin-like serine proteaseEpidermin leader peptide processing serine protease EpiPSubtilase cytotoxin subunit ASC:3Proprotein convertase subtilisin/kexin type 9Proprotein convertase subtilisin/kexin type 5Proprotein convertase type 2Subtilisin-like protease SBT1.5Subtilisin-like serine proteaseMembrane-bound transcription factor site-1 protease preproproteintripeptidyl-peptidase 2 isoform X1Putative neuroendocrine convertase 1subtilisin-like protease SBT6.1Tripeptidyl-peptidase 2 homologTripeptidyl peptidase AProtease S8 tripeptidyl peptidase IMinor extracellular proteaseProprotein convertase subtilisin/kexin type 5aExtracellular proteaseSubtilisin-like protease 2PeptidaseSubtilisin-like protease SBT4.12Peptidase S53 propeptideMicrobial collagenaseUncharacterized proteinSerine protease, putativeCell wall-associated serine proteinaseUncharacterized proteinProline rich membrane-anchored mycosinTripeptidyl peptidase ISerin endopeptidaseClan SB, family S8, subtilisin-like serine peptidasePredicted proteinPredicted proteinProline rich membrane-anchored mycosinProprotein convertase subtilisin/kexin type 5Peptidase S8Serine protease/ABC transporter B family protein tagCSerine protease AprXSubtilisin-like protease 3, putativeDipeptidyl aminopeptidasePeptidase S8 and S53 subtilisin kexin sedolisinSurface layer-associated STABLE protease, conjecturalUncharacterized proteinSerine protease, putativeSubtilisin-like serine proteaseUncharacterized proteinTk-subtilisinUncharacterized proteinAlkaline serine proteasePredicted proteinClan SB, family S8, subtilisin-like serine peptidaseTripeptidyl peptidase ISecreted subtilisin-like proteasePeptidase S53 propeptidep-domain proprotein convertase, putativeExtracellular serine proteaseFurin putative serine proteasePredicted proteinUncharacterized proteinp-domain proprotein convertase, putativeClan SB, family S8, subtilisin-like serine peptidaseGob-1Peptidase S8Uncharacterized proteinPeptidase S8 and S53 subtilisin kexin sedolisinUncharacterized proteinProprotein convertase subtilisin/kexin type 6Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPeptidase, S8/S53 familyExtracellular serine proteaseSerine protease, subtilisin familyUncharacterized proteinSerine proteaseUncharacterized proteinSerin endopeptidaseUncharacterized proteinS8 family serine proteaseSubtilisin-like serine proteaseProprotein convertase subtilisin/kexin type 5Tripeptidyl peptidase SED3 (AFU_orthologue AFUA_3G08930)Uncharacterized proteinUncharacterized proteinSerine protease (Putative secreted protein)Uncharacterized proteinSerine protease, subtilase familyUncharacterized proteinPeptidase S8/S53 domain-containing proteinRelated to microbial serine proteinaseNucleobase-ascorbate transporter 12Peptidase S8 and S53 subtilisin kexin sedolisinSubtilisin-like serine peptidase (Serine peptidase, clan sb, family s8-like protein)Alkaline serine protease AorO, putative (AFU_orthologue AFUA_6G10250)Serine protease AprXSubtilisin-like proteinYALI0C15532pUncharacterized proteinClan SB, family S8, subtilisin-like serine peptidaseClan SB, family S8, subtilisin-like serine peptidaseUncharacterized proteinNeuroendocrine convertase 1Predicted proteinClan SB, family S8, subtilisin-like serine peptidaseOs06g0163500 proteinTripeptidyl peptidase IProprotein convertase subtilisin/kexin type 4Uncharacterized proteinUncharacterized proteinClan SB, family S8, subtilisin-like serine peptidaseUncharacterized proteinPredicted proteinGlr3087 proteinUncharacterized proteinPredicted proteinOs01g0795400 proteinUncharacterized proteinClan SB, family S8, subtilisin-like serine peptidasePredicted proteinUncharacterized proteinClan SB, family S8, subtilisin-like serine peptidaseUncharacterized proteinFurin2, putativePredicted proteinGlr3087 proteinTripeptidyl peptidase IUncharacterized proteinTripeptidyl-peptidase 2-like proteinUncharacterized proteinUncharacterized proteinProbable subtilase-type serine protease DR_A0283Subtilisin-like serine endopeptidase family proteinUncharacterized proteinPredicted proteinUncharacterized proteinProprotein convertase subtilisin/kexin type 6Predicted proteinPredicted proteinTripeptidyl peptidase ISurface-associated serine proteasePredicted proteinUncharacterized proteinCollagenolytic serine proteaseProprotein convertase subtilisin/kexin type 4, furin, putativeSubtilisin-like serine peptidaseUncharacterized proteinSubtilisin-like alkaline protease, putativePredicted proteinPeptidase subtilase familyUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinMbtps1 proteinUncharacterized proteinPredicted proteinPredicted proteinUncharacterized proteinPutative subtilisin proteinase-like proteinPredicted proteinPapA proteinHypothetical phage proteinSubtilisin-like serine proteasePredicted proteinGll1055 proteinGll1055 proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinSurface layer-associated STABLE protease, conjecturalPredicted proteinUncharacterized proteinUncharacterized proteinProhormone convertase, putativeClan SB, family S8, subtilisin-like serine peptidasep-domain proprotein convertase, putativeUncharacterized proteinUncharacterized proteinPutative serine protease (Putative secreted protein)Peptidase S8 and S53 subtilisin kexin sedolisinUncharacterized proteinUncharacterized proteinProprotein convertase subtilisin/kexin type 4
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FunFam 12: Tripeptidyl-peptidase 1 preproprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
8 O89023 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
8 O89023 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Tripeptidyl-peptidase activity GO:0008240
Catalysis of the release of an N-terminal tripeptide from a polypeptide.
7 B5X2E6 (/ISS) F8W2M8 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
6 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 O14773 (/IDA) Q9EQV6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O14773 (/IPI) O89023 (/IPI)
Tripeptidyl-peptidase activity GO:0008240
Catalysis of the release of an N-terminal tripeptide from a polypeptide.
2 O14773 (/IDA) Q9EQV6 (/IDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O14773 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O89023 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 O14773 (/IMP)
Showing 1 to 10 of 18 entries

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9EQV6 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O14773 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O89023 (/ISO)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 O14773 (/TAS)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 O89023 (/IMP)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 O14773 (/ISS)
Showing 1 to 10 of 24 entries

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 O14773 (/IDA) O89023 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O89023 (/HDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O14773 (/IMP)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O89023 (/ISO)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
1 O14773 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O14773 (/HDA)
Showing 1 to 7 of 7 entries
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