The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase S8/S53 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Tripeptidyl-peptidase 1 preproprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
8 O89023 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
8 O89023 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Tripeptidyl-peptidase activity GO:0008240
Catalysis of the release of an N-terminal tripeptide from a polypeptide.
7 B5X2E6 (/ISS) F8W2M8 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
6 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 O14773 (/IDA) Q9EQV6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O14773 (/IPI) O89023 (/IPI)
Tripeptidyl-peptidase activity GO:0008240
Catalysis of the release of an N-terminal tripeptide from a polypeptide.
2 O14773 (/IDA) Q9EQV6 (/IDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O14773 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O89023 (/ISO)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 O14773 (/IMP)
Showing 1 to 10 of 18 entries

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Peptide catabolic process GO:0043171
The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 Q9EQV6 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O14773 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O89023 (/ISO)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
1 O14773 (/TAS)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 O89023 (/IMP)
Lysosome organization GO:0007040
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
1 O14773 (/ISS)
Showing 1 to 10 of 24 entries

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
10 B5X2E6 (/ISS) O89023 (/ISS) Q0V8B6 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5IS74 (/ISS) Q5RFL1 (/ISS) Q60HH1 (/ISS) Q9EQV6 (/ISS) Q9XSB8 (/ISS)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 O14773 (/IDA) O89023 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O89023 (/HDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O14773 (/IMP)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O89023 (/ISO)
Lysosomal lumen GO:0043202
The volume enclosed within the lysosomal membrane.
1 O14773 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O14773 (/HDA)
Showing 1 to 7 of 7 entries
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