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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: acyl-coenzyme A thioesterase 4

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Palmitoyl-CoA hydrolase. [EC: 3.1.2.2]
Palmitoyl-CoA + H(2)O = CoA + palmitate.
  • Also hydrolyzes CoA thioesters of other long-chain fatty acids.
 18 E9KL42 E9KL42 O55137 O55171 O88267 P49753 Q14032 Q53YL1 Q53YL1 Q63276
(8 more...)
Succinyl-CoA hydrolase. [EC: 3.1.2.3]
Succinyl-CoA + H(2)O = CoA + succinate.
    		 5 Q14DI6 Q14DI6 Q8BWN8 Q8BWN8 Q8N9L9
    Bile acid-CoA:amino acid N-acyltransferase. [EC: 2.3.1.65]
    Choloyl-CoA + glycine = CoA + glycocholate.
    • Also acts on CoA derivatives of other bile acids.
    • Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly.
    • Can also conjugate fatty acids to glycine and can act as a very-long- chain acyl-CoA thioesterase.
    • Bile-acid--amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol.
    • This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalyzed by EC 6.2.1.7.
    		 3 Q14032 Q63276 Q91X34