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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
alpha/beta hydrolase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Acyl-protein thioesterase 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
 31 O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA)
(21 more)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
 28 O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS)
(18 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
 28 O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA)
(18 more)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
 10 O77821 (/ISS) O77821 (/ISS) P70470 (/ISS) P97823 (/ISS) P97823 (/ISS) Q3MHR0 (/ISS) Q5RBR7 (/ISS) Q5RBR7 (/ISS) Q5RBR7 (/ISS) Q9QYL8 (/ISS)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
 3 P97823 (/ISO) P97823 (/ISO) Q9WTL7 (/ISO)
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
 3 C0PDF4 (/IDA) M9PEW1 (/IDA) Q9I7R0 (/IDA)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
 2 P97823 (/ISO) P97823 (/ISO)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
 2 O75608 (/TAS) O75608 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 2 Q6IAQ1 (/IPI) Q6IAQ1 (/IPI)
Palmitoyl-(protein) hydrolase activity GO:0008474
Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
 2 O75608 (/IMP) O75608 (/IMP)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
 2 O75608 (/IDA) O75608 (/IDA)
Lipase activity GO:0016298
Catalysis of the hydrolysis of a lipid or phospholipid.
 2 P97823 (/ISO) P97823 (/ISO)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
 1 P70470 (/IDA)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
 31 O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA)
(21 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
 28 O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS)
(18 more)
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
 2 P97823 (/IMP) P97823 (/IMP)
Negative regulation of Golgi to plasma membrane protein transport GO:0042997
Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.
 2 P97823 (/IMP) P97823 (/IMP)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
 2 O75608 (/TAS) O75608 (/TAS)
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
 1 Q9WTL7 (/ISO)
Protein depalmitoylation GO:0002084
The removal of palymitoyl groups from a lipoprotein.
 1 Q9QYL8 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 32 C0PDF4 (/IDA) M9PEW1 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA) O95372 (/IDA)
(22 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 30 O75608 (/TAS) O75608 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS) O95372 (/TAS)
(20 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 30 O75608 (/HDA) O75608 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA) O95372 (/HDA)
(20 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
 2 P97823 (/HDA) P97823 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 2 P97823 (/IDA) P97823 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 Q9WTL7 (/ISO)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
 1 Q9WTL7 (/IDA)