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CATH Superfamily 3.40.50.150

Vaccinia Virus protein VP39

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 285: tRNA (cytosine(38)-C(5))-methyltransferase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA (cytosine(38)-C(5))-methyltransferase. [EC: 2.1.1.204]
S-adenosyl-L-methionine + cytosine(38) in tRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(38) in tRNA.
  • The eukaryotic enzyme catalyzes methylation of cytosine(38) in the anti-codon loop of tRNA(Asp)(GTC), tRNA(Val)(AAC) and tRNA(Gly)(GCC).
  • Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease.
  • Formerly EC 2.1.1.29.
 10 O14717 O14717 O55055 O55055 Q4G073 Q5I0V6 Q5I0V6 Q6ICS7 Q6ICS7 Q7YS61
DNA (cytosine-5-)-methyltransferase. [EC: 2.1.1.37]
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
  • Formerly EC 2.1.1.73.
 1 Q54JH6
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