The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphoglycerate mutase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Phosphoglycerate mutase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphoglycerate mutase activity GO:0004619
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
30 O70250 (/IDA) O70250 (/IDA) P16290 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(20 more)
Phosphoglycerate mutase activity GO:0004619
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
27 P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P18669 (/IMP) P18669 (/IMP) P18669 (/IMP) P18669 (/IMP) P18669 (/IMP)
(17 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
23 O70250 (/IPI) O70250 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI)
(13 more)
Phosphoglycerate mutase activity GO:0004619
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
22 P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS) P18669 (/NAS)
(12 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
21 P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI) P18669 (/IPI)
(11 more)
Phosphoglycerate mutase activity GO:0004619
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.
5 O70250 (/ISO) O70250 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
3 Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity GO:0046538
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate.
2 O70250 (/ISO) O70250 (/ISO)
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
2 O70250 (/ISO) O70250 (/ISO)
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity GO:0046538
Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate.
1 P16290 (/IMP)
Cofactor binding GO:0048037
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
1 P16290 (/IMP)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
29 P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(19 more)
Canonical glycolysis GO:0061621
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
26 P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(16 more)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
23 O70250 (/IDA) O70250 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(13 more)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
21 P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(11 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
21 P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(11 more)
Regulation of pentose-phosphate shunt GO:0043456
Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.
21 P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(11 more)
Respiratory burst GO:0045730
A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
21 P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(11 more)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
6 P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) Q8N0Y7 (/IMP)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
5 O70250 (/ISO) O70250 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
5 P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP) P15259 (/IMP)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
3 Q5ZLN1 (/TAS) Q5ZLN1 (/TAS) Q5ZLN1 (/TAS)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
3 Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Regulation of pentose-phosphate shunt GO:0043456
Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.
3 Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Respiratory burst GO:0045730
A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
3 Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
2 O70250 (/ISO) O70250 (/ISO)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
2 O70250 (/ISO) O70250 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O70250 (/IDA) O70250 (/IDA)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
2 O70250 (/ISO) O70250 (/ISO)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
2 O70250 (/ISO) O70250 (/ISO)
Gluconeogenesis GO:0006094
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
1 P16290 (/IDA)
Glycolytic process GO:0006096
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
1 Q8N0Y7 (/NAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P16290 (/IEP)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q7T3G4 (/IMP)
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 P16290 (/IMP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 A0A060Z9H8 (/IDA)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
1 P16290 (/IMP)
Positive regulation of flagellated sperm motility GO:1902093
Any process that activates or increases the frequency, rate or extent of flagellated sperm motility.
1 Q8N0Y7 (/NAS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
29 P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P15259 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(19 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
27 P15259 (/HDA) P15259 (/HDA) P15259 (/HDA) P15259 (/HDA) P15259 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA)
(17 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
22 P16290 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(12 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
21 P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(11 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
21 P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA) P18669 (/IDA)
(11 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
21 P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA) P18669 (/HDA)
(11 more)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
21 P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(11 more)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
21 P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS) P18669 (/TAS)
(11 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
6 F1NHM9 (/IDA) F1NHM9 (/IDA) F1NHM9 (/IDA) Q5ZLN1 (/IDA) Q5ZLN1 (/IDA) Q5ZLN1 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P15259 (/HDA) P15259 (/HDA) P15259 (/HDA) P15259 (/HDA) P15259 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O70250 (/ISO) O70250 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O70250 (/ISO) O70250 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P16290 (/IDA) P25113 (/IDA) P25113 (/IDA) P25113 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9DBJ1 (/ISO) Q9DBJ1 (/ISO) Q9DBJ1 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
3 Q9DBJ1 (/HDA) Q9DBJ1 (/HDA) Q9DBJ1 (/HDA)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 Q8N0Y7 (/IDA)
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