The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"TPP-binding domain
".
FunFam 113: NAD-dependent histone deacetylase sir2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone deacetylase activity GO:0004407
Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
|
1 | O94640 (/IDA) |
|
Histone deacetylase activity (H3-K14 specific) GO:0031078
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.
|
1 | O94640 (/IDA) |
|
Histone deacetylase activity (H3-K9 specific) GO:0032129
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | O94640 (/IDA) |
|
Histone deacetylase activity (H4-K16 specific) GO:0034739
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
|
1 | O94640 (/IDA) |
|
NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.
|
1 | O94640 (/IDA) |
|
NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970
Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein.
|
1 | O94640 (/IDA) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
1 | O94640 (/IDA) |
|
Histone deacetylase activity (H3-K4 specific) GO:1990162
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein.
|
1 | O94640 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | O94640 (/IEP) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | O94640 (/IMP) |
|
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
|
1 | O94640 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | O94640 (/IDA) |
|
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
|
1 | O94640 (/IGI) |
|
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
|
1 | O94640 (/IMP) |
|
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
|
1 | O94640 (/IMP) |
|
Positive regulation of heterochromatin assembly GO:0031453
Any process that activates or increases the frequency, rate or extent of heterochromatin formation.
|
1 | O94640 (/EXP) |
|
Histone H3-K14 acetylation GO:0044154
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.
|
1 | O94640 (/IC) |
|
Regulation of histone H3-K9 methylation GO:0051570
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
|
1 | O94640 (/IMP) |
|
Protein localization to chromosome, telomeric region GO:0070198
Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.
|
1 | O94640 (/IMP) |
|
Histone H3-K4 deacetylation GO:1990596
The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone.
|
1 | O94640 (/IMP) |
|
Histone H3-K9 deacetylation GO:1990619
The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone.
|
1 | O94640 (/IMP) |
|
Histone H4-K16 deacetylation GO:1990678
The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone.
|
1 | O94640 (/IMP) |
|
Histone H4-K12 deacetylation GO:1990679
The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone.
|
1 | O94640 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | O94640 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94640 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O94640 (/IDA) |
|
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
1 | O94640 (/IDA) |
|
Mating-type region heterochromatin GO:0031934
Heterochromatic regions of the chromosome found at silenced mating-type loci.
|
1 | O94640 (/IDA) |
|
Nuclear rDNA heterochromatin GO:1902377
Any rDNA heterochromatin that is part of a nucleus.
|
1 | O94640 (/IDA) |
|
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
|
1 | O94640 (/IDA) |
