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CATH Superfamily 3.40.50.10860

Leucine Dehydrogenase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Leucine Dehydrogenase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Quinate/shikimate dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Shikimate 3-dehydrogenase (NADP+) activity GO:0004764
Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.
 66 O67049 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(56 more)
Quinate 3-dehydrogenase (NAD+) activity GO:0030266
Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+.
 66 P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(56 more)
NADP binding GO:0050661
Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
 66 O67049 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(56 more)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
 65 P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(55 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 65 P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI) P0A6D5 (/IPI)
(55 more)
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
 65 P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(55 more)
Shikimate 3-dehydrogenase (NAD+) activity GO:0052734
Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+.
 65 P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA) P0A6D5 (/IDA)
(55 more)
Quinate 3-dehydrogenase (NAD+) activity GO:0030266
Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+.
 6 A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) Q8FSF0 (/ISS)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
 6 A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) A4QB65 (/ISS) Q8FSF0 (/ISS)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
 1 Q9X5C9 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chorismate biosynthetic process GO:0009423
The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds.
 5 A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP)
Shikimate metabolic process GO:0019632
The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.
 5 A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP) A4QB65 (/IMP)
Chorismate biosynthetic process GO:0009423
The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds.
 2 O67049 (/IDA) Q9X5C9 (/IDA)
Shikimate metabolic process GO:0019632
The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.
 2 O67049 (/IDA) Q9X5C9 (/IDA)
Chorismate biosynthetic process GO:0009423
The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds.
 1 Q8FSF0 (/ISS)
Shikimate metabolic process GO:0019632
The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.
 1 Q8FSF0 (/ISS)

There are 0 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
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